Timing of Revascularization and Parenteral Antibiotic Treatment Associated with Therapeutic Failures in Ischemic Diabetic Foot Infections

• Published in: Antibiotics (Basel) Vol. 12; no. 4; p. 685
• Main Authors: Altmann, Dominique, Waibel, Felix W A, Forgo, Gabor, Grigorean, Alexandru, Lipsky, Benjamin A, Uçkay, Ilker, Schöni, Madlaina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.03.2023; MDPI
• Subjects: Amputation; Analysis; Angioplasty; Antibiotics; clinical and microbiological failures; Debridement; Diabetes; Diabetes mellitus; Diabetic foot; diabetic foot infection; Failure; Foot diseases; Infection; Infections; Ischemia; limb ischemia; parenteral antibiotic therapy; Pathogens; Patient compliance; Patients; peripheral arterial disease; Regression analysis; Statistical analysis; Surgery; Tazobactam; Therapy; Time lag; timing of angioplasty; Vascularization; Wound healing; parenteral antibiotic therapy; limb ischemia; peripheral arterial disease; clinical and microbiological failures; timing of angioplasty; diabetic foot infection

For ischemic diabetic foot infections (DFIs), revascularization ideally occurs before surgery, while a parenteral antibiotic treatment could be more efficacious than oral agents. In our tertiary center, we investigated the effects of the sequence between revascularization and surgery (emphasizing th...