Association study of interleukin-1 family and interleukin-6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis

• Published in: International journal of immunogenetics Vol. 42; no. 6; pp. 428 - 431
• Main Authors: Najafi, S., Yousefi, H., Mohammadzadeh, M., Bidoki, A. Z., Firouze Moqadam, I., Farhadi, E., Amirzargar, A. A., Rezaei, N.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2015
• Subjects: Adult; Alleles; Case-Control Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-1 - genetics; Interleukin-6 - genetics; Iran; Male; Middle Aged; Polymorphism, Single Nucleotide; Stomatitis, Aphthous - genetics; Young Adult; Iran

Summary Recurrent aphthous stomatitis (RAS) is a common painful, ulcerative oral inflammatory disorder with unknown aetiology. Immune system and aberrant cytokine cascade deemed to be critical in outbreaks of RAS ulcers. Interleukin‐1 (IL‐1) and IL‐6 are the most potent pro‐inflammatory cytokines. S...