A senescent cell bystander effect: senescence‐induced senescence

• Published in: Aging cell Vol. 11; no. 2; pp. 345 - 349
• Main Authors: Nelson, Glyn, Wordsworth, James, Wang, Chunfang, Jurk, Diana, Lawless, Conor, Martin‐Ruiz, Carmen, von Zglinicki, Thomas
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2012; John Wiley & Sons, Inc
• Subjects: 53BP1; aging; Bystander Effect; Cell Line; cell signalling; Cellular Senescence; Coculture Techniques; DNA Damage; fluorescence; GFP; Hepatocytes - cytology; Hepatocytes - metabolism; Humans; Original; Reactive Oxygen Species - metabolism; Rodents; Senescence

Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell grow...