A senescent cell bystander effect: senescence‐induced senescence
Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell grow...
Saved in:
| Published in | Aging cell Vol. 11; no. 2; pp. 345 - 349 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.04.2012
John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Summary
Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation‐competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction‐mediated cell–cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo. |
|---|---|
| AbstractList | Summary
Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation‐competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction‐mediated cell–cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours
in vitro
and, possibly,
in vivo
. Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation‐competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction‐mediated cell–cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo. Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation-competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction-mediated cell-cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo. [PUBLICATION ABSTRACT] Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation-competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction-mediated cell–cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo . Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation-competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction-mediated cell-cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo. |
| Author | Wordsworth, James Nelson, Glyn Jurk, Diana von Zglinicki, Thomas Lawless, Conor Martin‐Ruiz, Carmen Wang, Chunfang |
| Author_xml | – sequence: 1 givenname: Glyn surname: Nelson fullname: Nelson, Glyn – sequence: 2 givenname: James surname: Wordsworth fullname: Wordsworth, James – sequence: 3 givenname: Chunfang surname: Wang fullname: Wang, Chunfang – sequence: 4 givenname: Diana surname: Jurk fullname: Jurk, Diana – sequence: 5 givenname: Conor surname: Lawless fullname: Lawless, Conor – sequence: 6 givenname: Carmen surname: Martin‐Ruiz fullname: Martin‐Ruiz, Carmen – sequence: 7 givenname: Thomas surname: von Zglinicki fullname: von Zglinicki, Thomas |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22321662$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkctKw0AUhgep2Iu-ggRcuGqcSzIXQaGWeoGCm-6HZGaiCemkZhJtdz6Cz-iTmNgaqitnM4dzvvNzfv4h6NnCGgA8BH3UvIvMRwELxoJh6mOIsA8hE6G_PgCDbtDrasT7YOhcBiFiApIj0MeYYEQpHoCbieeMNU4ZW3nK5LkXb1wVWW1KzySJUdVlByjz-f6RWl0ro_eax-AwiXJnTnb_CCxuZ4vp_Xj-ePcwnczHKqQsHEecJyFFWBAqYkVJgjVkCqEYaQHDRFPElKIsYgEnTCgRa8ZCmgQhw5pDREbgeiu7quOl0e3BZZTLVZkuo3IjiyiVvyc2fZZPxaskAedY4EbgfCdQFi-1cZVcpq61HFlT1E4KzAXkmJOGPPtDZkVd2sacRGEQMCoIaSm-pVRZOFeapLsFQdnGJDPZJiDbNGQbk_yOSa6b1dN9L93iTy4NcLUF3tLcbP4tLCfT2bypyBdIRaM7 |
| CitedBy_id | crossref_primary_10_1016_j_devcel_2023_05_010 crossref_primary_10_3389_fcell_2021_793088 crossref_primary_10_3390_ijms232113059 crossref_primary_10_1016_j_redox_2024_103228 crossref_primary_10_1007_s11357_022_00652_x crossref_primary_10_7554_eLife_84238 crossref_primary_10_3390_toxins11020082 crossref_primary_10_1016_j_arr_2022_101608 crossref_primary_10_1007_s13238_015_0241_6 crossref_primary_10_1016_j_tma_2019_01_002 crossref_primary_10_1124_molpharm_123_000803 crossref_primary_10_1038_s41420_020_00393_w crossref_primary_10_3389_fgene_2018_00623 crossref_primary_10_18632_aging_203405 crossref_primary_10_1016_j_neurobiolaging_2019_02_010 crossref_primary_10_3390_biomedicines9091162 crossref_primary_10_1016_j_tcb_2018_04_006 crossref_primary_10_1016_j_brainres_2022_147925 crossref_primary_10_1016_j_freeradbiomed_2013_12_021 crossref_primary_10_3390_ph17030312 crossref_primary_10_1111_acel_13296 crossref_primary_10_1016_j_mad_2021_111539 crossref_primary_10_1016_j_arr_2021_101458 crossref_primary_10_1038_s43587_023_00447_5 crossref_primary_10_1073_pnas_1612290113 crossref_primary_10_1016_j_biocel_2013_07_004 crossref_primary_10_1016_j_arr_2021_101456 crossref_primary_10_1038_s41467_024_48443_6 crossref_primary_10_1016_j_mad_2021_111540 crossref_primary_10_1111_febs_16361 crossref_primary_10_3390_ijms21010349 crossref_primary_10_3389_fphar_2021_728100 crossref_primary_10_1007_s10522_023_10047_w crossref_primary_10_1016_j_cell_2013_05_039 crossref_primary_10_1016_j_fitote_2017_10_010 crossref_primary_10_1051_e3sconf_202124503051 crossref_primary_10_1038_nm_4385 crossref_primary_10_18632_oncotarget_4932 crossref_primary_10_1111_cpr_13323 crossref_primary_10_1186_s43042_022_00335_4 crossref_primary_10_1007_s00281_020_00816_x crossref_primary_10_3390_ijms232213920 crossref_primary_10_1126_sciadv_adj2102 crossref_primary_10_1016_j_semcancer_2019_06_018 crossref_primary_10_18632_aging_101404 crossref_primary_10_1042_CS20190966 crossref_primary_10_1172_JCI162519 crossref_primary_10_3390_ijms19102937 crossref_primary_10_1016_j_arr_2024_102273 crossref_primary_10_1152_ajpcell_00062_2020 crossref_primary_10_3389_fcell_2020_591067 crossref_primary_10_1111_acel_13270 crossref_primary_10_5812_jjnpp_133171 crossref_primary_10_1007_s10522_017_9736_2 crossref_primary_10_1038_s41598_017_11487_4 crossref_primary_10_3389_fnins_2022_824191 crossref_primary_10_1016_j_jhep_2016_05_030 crossref_primary_10_3389_fragi_2021_797320 crossref_primary_10_1152_ajplung_00574_2020 crossref_primary_10_3390_jpm12050716 crossref_primary_10_1128_JVI_00794_21 crossref_primary_10_15252_embj_2020106048 crossref_primary_10_1007_s00204_020_02946_5 crossref_primary_10_1007_s11897_021_00519_w crossref_primary_10_1136_annrheumdis_2020_217072 crossref_primary_10_1016_j_jjcc_2019_05_002 crossref_primary_10_1155_2014_360438 crossref_primary_10_1038_s41419_017_0069_5 crossref_primary_10_3389_fpubh_2024_1385387 crossref_primary_10_1021_acs_jmedchem_3c00503 crossref_primary_10_1038_nm_4000 crossref_primary_10_1152_ajprenal_00195_2016 crossref_primary_10_1002_cbin_11536 crossref_primary_10_1002_mnfr_202300330 crossref_primary_10_3390_ijms19051327 crossref_primary_10_1016_j_envres_2024_119483 crossref_primary_10_1134_S0362119720010132 crossref_primary_10_1038_s41467_023_40393_9 crossref_primary_10_1016_j_ebiom_2019_01_056 crossref_primary_10_3389_fendo_2024_1298423 crossref_primary_10_1080_01635581_2020_1870705 crossref_primary_10_1371_journal_pbio_3000599 crossref_primary_10_3390_ijms232113085 crossref_primary_10_1038_s41568_022_00450_9 crossref_primary_10_1038_nature13193 crossref_primary_10_1016_j_freeradbiomed_2019_01_016 crossref_primary_10_1158_1535_7163_MCT_17_0288 crossref_primary_10_18632_aging_102863 crossref_primary_10_1016_j_bone_2019_01_015 crossref_primary_10_1016_j_arr_2021_101412 crossref_primary_10_1016_j_mad_2021_111583 crossref_primary_10_18632_aging_204701 crossref_primary_10_1016_j_mad_2021_111585 crossref_primary_10_1126_scitranslmed_aax3799 crossref_primary_10_1111_acel_13486 crossref_primary_10_1016_j_jare_2024_03_006 crossref_primary_10_3389_fnagi_2022_933015 crossref_primary_10_1038_nrm3823 crossref_primary_10_1093_biolre_ioaa113 crossref_primary_10_3390_ijerph16050792 crossref_primary_10_1016_j_phymed_2024_155679 crossref_primary_10_1002_jcp_30687 crossref_primary_10_1038_s43587_022_00285_x crossref_primary_10_1016_j_placenta_2022_03_005 crossref_primary_10_18632_aging_101328 crossref_primary_10_1111_acel_13338 crossref_primary_10_3390_ijms222313173 crossref_primary_10_1016_j_arr_2019_100998 crossref_primary_10_1210_endrev_bnac008 crossref_primary_10_1155_2021_9032378 crossref_primary_10_1186_1471_213X_14_21 crossref_primary_10_3390_cells11111781 crossref_primary_10_1021_acs_jproteome_7b00536 crossref_primary_10_1111_prd_12380 crossref_primary_10_1155_2022_4842316 crossref_primary_10_3390_antiox12061250 crossref_primary_10_7554_eLife_05505 crossref_primary_10_3389_fevo_2021_685057 crossref_primary_10_3390_ijms25074092 crossref_primary_10_1093_carcin_bgz118 crossref_primary_10_14336_AD_2021_0110 crossref_primary_10_1111_acel_13468 crossref_primary_10_1080_15384101_2021_1909260 crossref_primary_10_3389_fnagi_2022_827900 crossref_primary_10_1371_journal_pcbi_1003728 crossref_primary_10_1038_nm_4324 crossref_primary_10_1242_jcs_109728 crossref_primary_10_3389_fimmu_2019_02531 crossref_primary_10_3390_ijms23094653 crossref_primary_10_1016_j_arr_2018_11_002 crossref_primary_10_1111_acel_13550 crossref_primary_10_1172_JCI95148 crossref_primary_10_1016_j_exger_2017_10_015 crossref_primary_10_1101_gad_343129_120 crossref_primary_10_1186_s13287_017_0688_x crossref_primary_10_3390_cells12242769 crossref_primary_10_7554_eLife_75492 crossref_primary_10_1042_BST20190109 crossref_primary_10_3389_fgene_2015_00094 crossref_primary_10_18632_aging_204347 crossref_primary_10_1016_j_freeradbiomed_2018_10_417 crossref_primary_10_1038_s41467_022_32552_1 crossref_primary_10_2174_1574888X15666200422103916 crossref_primary_10_1073_pnas_2311028121 crossref_primary_10_7554_eLife_84088 crossref_primary_10_3389_fphar_2018_00522 crossref_primary_10_3390_antiox11030480 crossref_primary_10_1007_s10522_018_9769_1 crossref_primary_10_1007_s00702_023_02638_1 crossref_primary_10_1080_15384101_2022_2092180 crossref_primary_10_18632_aging_203588 crossref_primary_10_3390_tropicalmed7070129 crossref_primary_10_14336_AD_2024_0280 crossref_primary_10_1177_00220345231154567 crossref_primary_10_3390_ijms222212232 crossref_primary_10_3389_fcell_2020_00103 crossref_primary_10_1007_s12326_021_00452_8 crossref_primary_10_1038_ncb2784 crossref_primary_10_1098_rsob_190168 crossref_primary_10_2337_db14_1820 crossref_primary_10_3892_ijo_2018_4553 crossref_primary_10_3390_ijms161025392 crossref_primary_10_1016_j_gde_2014_06_009 crossref_primary_10_3390_nu11112553 crossref_primary_10_1016_j_ajog_2017_11_567 crossref_primary_10_18632_aging_204207 crossref_primary_10_1016_j_arr_2023_102001 crossref_primary_10_1155_2021_6697861 crossref_primary_10_1111_acel_13301 crossref_primary_10_1016_j_biomaterials_2024_122659 crossref_primary_10_1038_s43587_021_00107_6 crossref_primary_10_3389_fncel_2020_00016 crossref_primary_10_1007_s12035_018_1112_y crossref_primary_10_3390_ijms22094402 crossref_primary_10_1016_j_celrep_2019_05_095 crossref_primary_10_1038_s41556_018_0206_0 crossref_primary_10_1161_JAHA_120_020712 crossref_primary_10_1152_ajpheart_00287_2018 crossref_primary_10_1016_j_mad_2018_06_004 crossref_primary_10_1111_acel_13875 crossref_primary_10_1007_s00441_021_03496_7 crossref_primary_10_3803_EnM_2023_1727 crossref_primary_10_1038_s41584_020_00533_7 crossref_primary_10_1038_s41575_024_00913_4 crossref_primary_10_3389_fphar_2023_1172920 crossref_primary_10_3389_fncel_2020_00129 crossref_primary_10_3390_cancers12040822 crossref_primary_10_1038_s41419_019_1607_0 crossref_primary_10_1038_s41574_021_00555_5 crossref_primary_10_3389_fcvm_2023_1142575 crossref_primary_10_1016_j_trsl_2020_06_007 crossref_primary_10_18632_oncotarget_28587 crossref_primary_10_1016_j_envpol_2021_118043 crossref_primary_10_4161_15384101_2014_985507 crossref_primary_10_1007_s00109_018_1686_x crossref_primary_10_1152_ajpcell_00178_2023 crossref_primary_10_1016_j_ajps_2017_12_003 crossref_primary_10_1007_s10522_015_9554_3 crossref_primary_10_1016_j_mad_2022_111709 crossref_primary_10_1016_j_cellsig_2020_109771 crossref_primary_10_1007_s40618_020_01255_z crossref_primary_10_1002_cyto_a_24852 crossref_primary_10_1016_j_jid_2016_01_017 crossref_primary_10_1016_j_jiec_2017_08_053 crossref_primary_10_1111_acel_12646 crossref_primary_10_2139_ssrn_3380253 crossref_primary_10_1039_D3NR04083F crossref_primary_10_1186_s13045_023_01426_4 crossref_primary_10_1016_j_ebiom_2018_09_015 crossref_primary_10_1016_j_exger_2021_111588 crossref_primary_10_1111_acel_12882 crossref_primary_10_1136_thoraxjnl_2019_213064 crossref_primary_10_3892_mmr_2020_11102 crossref_primary_10_59541_001c_117234 crossref_primary_10_3389_fendo_2018_00258 crossref_primary_10_3390_cells11030359 crossref_primary_10_1016_j_canlet_2013_09_005 crossref_primary_10_1016_j_canlet_2013_09_006 crossref_primary_10_1002_hep_26993 crossref_primary_10_1038_s41585_023_00827_x crossref_primary_10_1016_j_freeradbiomed_2017_10_379 crossref_primary_10_1016_j_redox_2016_11_005 crossref_primary_10_1242_dev_138222 crossref_primary_10_3389_fmed_2022_908639 crossref_primary_10_1038_s41420_021_00570_5 crossref_primary_10_3389_fimmu_2018_00586 crossref_primary_10_3390_ijms22094559 crossref_primary_10_3390_ijms23052701 crossref_primary_10_1371_journal_pone_0077157 crossref_primary_10_1038_ncb3203 crossref_primary_10_3390_biology11101419 crossref_primary_10_1038_s12276_022_00727_x crossref_primary_10_1253_circj_CJ_23_0419 crossref_primary_10_1089_rej_2018_2115 crossref_primary_10_3390_ijms23116135 crossref_primary_10_1038_srep14391 crossref_primary_10_3390_cells10123367 crossref_primary_10_1371_journal_pone_0068003 crossref_primary_10_1093_braincomms_fcab117 crossref_primary_10_3389_fcell_2020_00282 crossref_primary_10_1007_s00109_020_01988_7 crossref_primary_10_1016_j_jid_2020_11_018 crossref_primary_10_1186_s13287_021_02271_3 crossref_primary_10_1016_j_jid_2020_11_010 crossref_primary_10_1093_bib_bbv062 crossref_primary_10_1111_acel_12741 crossref_primary_10_1016_j_ejcb_2020_151108 crossref_primary_10_1016_j_maturitas_2016_06_008 crossref_primary_10_1371_journal_pone_0115686 crossref_primary_10_1124_molpharm_124_000871 crossref_primary_10_1186_s13578_022_00815_5 crossref_primary_10_1007_s10522_024_10114_w crossref_primary_10_1111_apt_14802 crossref_primary_10_3390_bioengineering10111274 crossref_primary_10_1016_j_mad_2024_111918 crossref_primary_10_1016_j_mrrev_2023_108474 crossref_primary_10_2174_1871523019666200512114210 crossref_primary_10_1007_s12602_021_09903_3 crossref_primary_10_3390_cells8070686 crossref_primary_10_3389_fcell_2020_00059 crossref_primary_10_1016_j_tins_2021_06_007 crossref_primary_10_1016_j_bbcan_2020_188424 crossref_primary_10_1016_j_exger_2015_04_014 crossref_primary_10_1200_JCO_2017_76_7467 crossref_primary_10_1080_2162402X_2016_1183860 crossref_primary_10_1007_s42978_019_0015_6 crossref_primary_10_1016_j_semcdb_2019_10_015 crossref_primary_10_3389_fgene_2019_00948 crossref_primary_10_3390_nu11010053 crossref_primary_10_3390_ijms24065132 crossref_primary_10_1111_acel_12601 crossref_primary_10_1128_JVI_01061_20 crossref_primary_10_1371_journal_pone_0055190 crossref_primary_10_1007_s00018_019_03420_x crossref_primary_10_3390_cells9122659 crossref_primary_10_1111_acel_12848 crossref_primary_10_1016_j_exger_2022_112070 crossref_primary_10_12677_ACM_2023_1371700 crossref_primary_10_18632_aging_204273 crossref_primary_10_1111_acel_12841 crossref_primary_10_18632_aging_205245 crossref_primary_10_1371_journal_pone_0151869 crossref_primary_10_1002_1873_3468_12902 crossref_primary_10_1146_annurev_cellbio_120420_013537 crossref_primary_10_1038_s41591_018_0092_9 crossref_primary_10_1096_fba_2020_00058 crossref_primary_10_3390_antiox11122413 crossref_primary_10_1016_j_ydbio_2013_03_015 crossref_primary_10_1093_molehr_gaac039 crossref_primary_10_1242_dev_191957 crossref_primary_10_1186_s13287_020_01782_9 crossref_primary_10_1371_journal_pone_0091005 crossref_primary_10_3390_antiox10091497 crossref_primary_10_1038_cddis_2016_275 crossref_primary_10_1038_ncomms4837 crossref_primary_10_3233_JAD_161221 crossref_primary_10_5124_jkma_2021_64_6_438 crossref_primary_10_1007_s13577_015_0110_x crossref_primary_10_7554_eLife_12997 crossref_primary_10_3389_fnagi_2019_00143 crossref_primary_10_1111_micc_12487 crossref_primary_10_1186_s13075_022_02859_x crossref_primary_10_1002_adbi_202101166 crossref_primary_10_3390_ijms25126687 crossref_primary_10_1016_j_tem_2016_09_005 crossref_primary_10_7554_eLife_69958 crossref_primary_10_3390_ijtm3010011 crossref_primary_10_3390_pharmaceutics14091955 crossref_primary_10_1111_acel_12945 crossref_primary_10_1093_lifemedi_lnac030 crossref_primary_10_1002_jcp_26511 crossref_primary_10_1038_s41419_020_03074_9 crossref_primary_10_1016_j_molmed_2020_03_005 crossref_primary_10_1097_RD9_0000000000000076 crossref_primary_10_1093_carcin_bgaa071 crossref_primary_10_1016_j_metabol_2021_154923 crossref_primary_10_1016_j_mad_2022_111689 crossref_primary_10_1186_s12951_024_02501_9 crossref_primary_10_1186_s12964_017_0172_3 crossref_primary_10_3390_ijms24032002 crossref_primary_10_1111_acel_12838 crossref_primary_10_1093_burnst_tkaa021 crossref_primary_10_1186_s40779_023_00485_5 crossref_primary_10_1007_s40610_022_00149_8 crossref_primary_10_15252_embj_201592862 crossref_primary_10_1016_j_cell_2021_09_034 crossref_primary_10_14336_AD_2021_0904 crossref_primary_10_1016_j_biopha_2023_115134 crossref_primary_10_3389_fonc_2022_913314 crossref_primary_10_3389_fphar_2022_1059434 crossref_primary_10_3390_ijms21072269 crossref_primary_10_1016_j_celrep_2019_03_104 crossref_primary_10_1016_j_bone_2019_115220 crossref_primary_10_1016_j_maturitas_2021_02_006 crossref_primary_10_1101_gad_320937_118 crossref_primary_10_1016_j_cmet_2018_12_008 crossref_primary_10_1038_s41514_017_0012_0 crossref_primary_10_1371_journal_pone_0160791 crossref_primary_10_3389_fragi_2022_926627 crossref_primary_10_1021_acsami_3c01322 crossref_primary_10_1016_j_yexmp_2021_104674 crossref_primary_10_3390_cancers6020741 crossref_primary_10_1007_s00018_020_03716_3 crossref_primary_10_1007_s00011_022_01598_8 crossref_primary_10_11648_j_bs_20241001_12 crossref_primary_10_12997_jla_2020_9_1_79 crossref_primary_10_1371_journal_pone_0196154 crossref_primary_10_18632_aging_205577 crossref_primary_10_1007_s11357_018_0018_y crossref_primary_10_1002_jbmr_2892 crossref_primary_10_1007_s11914_020_00619_x crossref_primary_10_1016_j_jeoa_2022_100423 crossref_primary_10_1016_j_stem_2017_01_008 crossref_primary_10_18632_aging_203396 crossref_primary_10_3390_ijms23052543 crossref_primary_10_1002_JPER_20_0529 crossref_primary_10_1073_pnas_1810692116 crossref_primary_10_4012_dmj_2022_242 crossref_primary_10_1016_j_smim_2019_04_003 crossref_primary_10_3389_fphar_2020_00755 crossref_primary_10_2139_ssrn_3910802 crossref_primary_10_1016_j_arr_2021_101280 crossref_primary_10_3389_fimmu_2021_671479 crossref_primary_10_3390_cells10010174 crossref_primary_10_3389_fimmu_2021_700790 crossref_primary_10_1177_2040622320964125 crossref_primary_10_3389_fcell_2020_620089 crossref_primary_10_3390_ijms24065862 crossref_primary_10_1101_gad_331272_119 crossref_primary_10_3390_cells13080659 crossref_primary_10_3390_ijms24129814 crossref_primary_10_7124_bc_0008F4 crossref_primary_10_1038_s43587_021_00121_8 crossref_primary_10_1186_s12967_023_04182_8 crossref_primary_10_1002_1873_3468_13498 crossref_primary_10_1002_mnfr_201901231 crossref_primary_10_1016_j_redox_2018_03_007 crossref_primary_10_3389_fcvm_2018_00043 crossref_primary_10_1016_j_mayocp_2014_01_020 crossref_primary_10_3389_fgene_2024_1345459 crossref_primary_10_1007_s00018_019_03374_0 crossref_primary_10_1016_j_copbio_2022_102737 crossref_primary_10_1021_acsnano_3c07807 crossref_primary_10_15252_embj_2019101982 crossref_primary_10_3389_ftox_2024_1360359 crossref_primary_10_1172_JCI64098 crossref_primary_10_3389_fimmu_2021_714742 crossref_primary_10_3390_bioengineering11010028 crossref_primary_10_1093_gerona_glw154 crossref_primary_10_1111_nan_12202 crossref_primary_10_1042_EBC20160087 crossref_primary_10_3389_fcvm_2018_00018 crossref_primary_10_1089_rej_2014_1623 crossref_primary_10_18632_aging_102441 crossref_primary_10_1016_j_mad_2017_07_001 crossref_primary_10_1039_D0BM01297A crossref_primary_10_1016_j_mad_2017_07_007 crossref_primary_10_1038_s41583_020_0325_z crossref_primary_10_1016_j_placenta_2020_05_003 crossref_primary_10_1007_s10522_019_09796_4 crossref_primary_10_1016_j_pharmthera_2020_107751 crossref_primary_10_1089_ten_tec_2018_0031 crossref_primary_10_7554_eLife_72449 crossref_primary_10_1186_1471_2318_14_42 crossref_primary_10_1111_j_1474_9726_2012_00870_x crossref_primary_10_1155_2019_2324193 crossref_primary_10_1038_s41536_023_00304_4 crossref_primary_10_1093_jnen_nlac048 crossref_primary_10_3390_cells12182287 crossref_primary_10_18632_aging_101026 crossref_primary_10_1172_JCI148073 crossref_primary_10_1016_j_ecoenv_2024_116392 crossref_primary_10_3390_ijms21207441 crossref_primary_10_1016_j_phrs_2016_05_015 crossref_primary_10_1016_j_placenta_2017_01_116 crossref_primary_10_1016_j_mce_2016_08_047 crossref_primary_10_1016_j_ymthe_2023_04_022 crossref_primary_10_18632_oncotarget_5899 crossref_primary_10_1159_000516668 crossref_primary_10_1038_s41568_019_0156_2 crossref_primary_10_1038_s41598_021_02658_5 crossref_primary_10_1111_febs_16325 crossref_primary_10_1016_j_mad_2024_111957 crossref_primary_10_1016_j_bbabio_2015_05_017 crossref_primary_10_1186_s40364_020_00257_6 crossref_primary_10_1159_000484088 crossref_primary_10_3389_fcell_2021_645593 crossref_primary_10_1186_2046_2395_3_1 crossref_primary_10_3390_biology9080191 crossref_primary_10_1039_D2FO01673G crossref_primary_10_1152_ajplung_00424_2018 crossref_primary_10_1111_cpr_12319 crossref_primary_10_3389_fonc_2018_00164 crossref_primary_10_31491_APT_2022_06_083 crossref_primary_10_1172_JCI154888 crossref_primary_10_1155_2015_732914 crossref_primary_10_1038_onc_2015_162 crossref_primary_10_1038_s41569_022_00739_0 crossref_primary_10_1016_j_mad_2023_111792 crossref_primary_10_3390_cancers13194933 crossref_primary_10_3389_fphar_2021_716517 crossref_primary_10_3389_fphys_2023_1297637 crossref_primary_10_1016_j_mad_2017_08_005 crossref_primary_10_1016_j_bbadis_2022_166352 crossref_primary_10_1016_j_ebiom_2017_03_020 crossref_primary_10_1080_15384101_2020_1728016 crossref_primary_10_1007_s11357_013_9603_2 crossref_primary_10_1038_ncomms5172 crossref_primary_10_1016_j_mad_2014_03_004 crossref_primary_10_1038_s41467_021_22131_1 crossref_primary_10_1111_acel_13188 crossref_primary_10_1111_febs_15570 crossref_primary_10_1016_j_arr_2018_01_002 crossref_primary_10_3390_ijms22020590 |
| Cites_doi | 10.1038/msb.2010.5 10.1016/j.mrfmmm.2009.04.006 10.1073/pnas.211053698 10.1111/j.1474-9726.2009.00481.x 10.1371/journal.pbio.0060301 10.1242/jcs.01651 10.1016/j.cell.2008.06.049 10.1038/nature10600 10.1242/jcs.071340 10.1158/0008-5472.CAN-06-3452 10.1016/j.cell.2008.03.039 10.1111/j.1474-9726.2010.00608.x 10.1667/RR1658.1 10.1091/mbc.E07-03-0280 10.1038/nrc2603 10.1089/rej.2007.0628 10.1158/0008-5472.CAN-05-1716 10.4161/cc.8.20.9857 10.18632/aging.100196 10.1038/nrm2233 |
| ContentType | Journal Article |
| Copyright | 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2012 |
| Copyright_xml | – notice: 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland – notice: 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. – notice: 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2012 |
| DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7TK 7X8 5PM |
| DOI | 10.1111/j.1474-9726.2012.00795.x |
| DatabaseName | Wiley_OA刊 Wiley Online Library Free Content Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Calcium & Calcified Tissue Abstracts Neurosciences Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Calcium & Calcified Tissue Abstracts Neurosciences Abstracts MEDLINE - Academic |
| DatabaseTitleList | CrossRef Calcium & Calcified Tissue Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1474-9726 |
| EndPage | 349 |
| ExternalDocumentID | 3371256971 10_1111_j_1474_9726_2012_00795_x 22321662 ACEL795 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Medical Research Council grantid: G0900686 – fundername: Biotechnology and Biological Sciences Research Council grantid: BB ⁄ C008200 ⁄ 1 – fundername: Medical Research Council grantid: G0601333 – fundername: Biotechnology and Biological Sciences Research Council grantid: BB/F010966/1 – fundername: Biotechnology and Biological Sciences Research Council grantid: BB/I020748/1 |
| GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 1OC 23M 24P 2WC 31~ 36B 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52W 52X 53G 5GY 5HH 5LA 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8FE 8FH 8UM 930 A01 A03 AAHHS AAZKR ABCQN ABDBF ABEML ABJNI ACCFJ ACGFO ACGFS ACPRK ACSCC ACXQS ADBBV ADKYN ADRAZ ADZMN ADZOD AEEZP AEGXH AENEX AEQDE AFBPY AFEBI AFKRA AFZJQ AIAGR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU BAWUL BBNVY BCNDV BENPR BFHJK BHPHI BY8 CAG CCPQU COF CS3 D-6 D-7 D-E D-F DIK DR2 E3Z EAD EAP EBD EBS EJD EMB EMK EMOBN EST ESX F00 F01 F04 F5P FIJ GODZA GROUPED_DOAJ GX1 HCIFZ HF~ HOLLA HZ~ IAO IHE IHR IPNFZ IX1 J0M K.9 KQ8 LC2 LC3 LH4 LK8 LP6 LP7 LW6 M48 M7P MK4 N04 N05 N9A O9- OBS OIG OK1 OVD P2P P2X P2Z P4B P4D PIMPY Q11 ROL RPM RX1 SUPJJ SV3 TEORI TR2 TUS UB1 V8K W8V WIN WQJ WRC WXI XG1 YFH YUY ~IA ~WT CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7TK 7X8 5PM |
| ID | FETCH-LOGICAL-c5675-a88f56129369bc63f2d07c11b1d905fd617cc67a748379c9bd7756f4572d8013 |
| IEDL.DBID | RPM |
| ISSN | 1474-9718 |
| IngestDate | Tue Sep 17 21:19:52 EDT 2024 Sat Aug 17 02:50:32 EDT 2024 Fri Sep 13 00:32:10 EDT 2024 Fri Aug 23 02:54:56 EDT 2024 Thu May 23 23:39:30 EDT 2024 Sat Aug 24 00:53:59 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#onlineopen_Terms |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5675-a88f56129369bc63f2d07c11b1d905fd617cc67a748379c9bd7756f4572d8013 |
| Notes | http://wileyonlinelibrary.com/onlineopen#onlineopen_Terms These authors contributed equally to this work. Re‐use of this article is permitted in accordance with the Terms and Conditions set out at ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488292/ |
| PMID | 22321662 |
| PQID | 1544769333 |
| PQPubID | 1036381 |
| PageCount | 5 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3488292 proquest_miscellaneous_928908283 proquest_journals_1544769333 crossref_primary_10_1111_j_1474_9726_2012_00795_x pubmed_primary_22321662 wiley_primary_10_1111_j_1474_9726_2012_00795_x_ACEL795 |
| PublicationCentury | 2000 |
| PublicationDate | April 2012 |
| PublicationDateYYYYMMDD | 2012-04-01 |
| PublicationDate_xml | – month: 04 year: 2012 text: April 2012 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: England – name: London |
| PublicationTitle | Aging cell |
| PublicationTitleAlternate | Aging Cell |
| PublicationYear | 2012 |
| Publisher | Blackwell Publishing Ltd John Wiley & Sons, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: John Wiley & Sons, Inc |
| References | 2011; 479 2007; 18 2011; 124 2006; 66 2009; 171 2007; 8 2005; 118 2009; 9 2009; 8 2008; 6 2008; 11 2008; 134 2008; 133 2010; 2 2007; 67 2010; 6 2009; 666 2010; 9 2001; 98 e_1_2_4_3_1 e_1_2_4_2_1 e_1_2_4_5_1 e_1_2_4_4_1 e_1_2_4_7_1 e_1_2_4_6_1 e_1_2_4_9_1 e_1_2_4_8_1 e_1_2_4_21_1 e_1_2_4_10_1 e_1_2_4_20_1 e_1_2_4_11_1 e_1_2_4_12_1 e_1_2_4_13_1 e_1_2_4_14_1 e_1_2_4_15_1 e_1_2_4_16_1 e_1_2_4_18_1 e_1_2_4_17_1 e_1_2_4_19_1 |
| References_xml | – volume: 133 start-page: 1019 year: 2008 end-page: 1031 article-title: Oncogene‐induced senescence relayed by an interleukin‐dependent inflammatory network publication-title: Cell – volume: 9 start-page: 667 year: 2010 end-page: 684 article-title: Fat tissue, aging, and cellular senescence publication-title: Aging Cell – volume: 171 start-page: 513 year: 2009 end-page: 520 article-title: Propagation distance of the alpha‐particle‐induced bystander effect: the role of nuclear traversal and gap junction communication publication-title: Radiat. Res. – volume: 8 start-page: 729 year: 2007 end-page: 740 article-title: Cellular senescence: when bad things happen to good cells publication-title: Nat. Rev. Mol. Cell Biol. – volume: 666 start-page: 68 year: 2009 end-page: 73 article-title: Up‐regulation of ROS by mitochondria‐dependent bystander signaling contributes to genotoxicity of bystander effects publication-title: Mutat. Res. – volume: 11 start-page: 449 year: 2008 end-page: 453 article-title: Role of insulin‐like growth factor binding protein‐3 in human umbilical vein endothelial cell senescence publication-title: Rejuvenation Res. – volume: 6 start-page: 2853 year: 2008 end-page: 2868 article-title: Senescence‐associated secretory phenotypes reveal cell‐nonautonomous functions of oncogenic RAS and the p53 tumor suppressor publication-title: PLoS Biol. – volume: 8 start-page: 3379 year: 2009 end-page: 3383 article-title: DNA damage foci in mitosis are devoid of 53BP1 publication-title: Cell Cycle – volume: 2 start-page: 555 year: 2010 end-page: 566 article-title: Adult‐onset, short‐term dietary restriction reduces cell senescence in mice publication-title: Aging (Albany NY) – volume: 124 start-page: 68 issue: Pt 1 year: 2011 end-page: 81 article-title: DNA‐SCARS: distinct nuclear structures that sustain damage‐induced senescence growth arrest and inflammatory cytokine secretion publication-title: J. Cell Sci. – volume: 66 start-page: 794 year: 2006 end-page: 802 article-title: The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms publication-title: Cancer Res. – volume: 18 start-page: 4543 year: 2007 end-page: 4552 article-title: Induction of cellular senescence by insulin‐like growth factor binding protein‐5 through a p53‐dependent mechanism publication-title: Mol. Biol. Cell – volume: 8 start-page: 311 year: 2009 end-page: 323 article-title: DNA damage response and cellular senescence in tissues of aging mice publication-title: Aging Cell – volume: 479 start-page: 232 year: 2011 end-page: 236 article-title: Clearance of p16Ink4a‐positive senescent cells delays ageing‐associated disorders publication-title: Nature – volume: 98 start-page: 12072 year: 2001 end-page: 12077 article-title: Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging publication-title: Proc. Natl Acad. Sci. USA – volume: 67 start-page: 3117 year: 2007 end-page: 3126 article-title: Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion publication-title: Cancer Res. – volume: 9 start-page: 351 year: 2009 end-page: 360 article-title: Radiation‐induced bystander signalling in cancer therapy publication-title: Nat. Rev. Cancer – volume: 134 start-page: 657 year: 2008 end-page: 667 article-title: Senescence of activated stellate cells limits liver fibrosis publication-title: Cell – volume: 118 start-page: 743 issue: Pt 4 year: 2005 end-page: 758 article-title: Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF‐beta1 signaling pathway publication-title: J. Cell Sci. – volume: 6 start-page: 347 year: 2010 article-title: Feedback between p21 and reactive oxygen production is necessary for cell senescence publication-title: Mol. Syst. Biol. – ident: e_1_2_4_16_1 doi: 10.1038/msb.2010.5 – ident: e_1_2_4_5_1 doi: 10.1016/j.mrfmmm.2009.04.006 – ident: e_1_2_4_11_1 doi: 10.1073/pnas.211053698 – ident: e_1_2_4_20_1 doi: 10.1111/j.1474-9726.2009.00481.x – ident: e_1_2_4_6_1 doi: 10.1371/journal.pbio.0060301 – ident: e_1_2_4_7_1 doi: 10.1242/jcs.01651 – ident: e_1_2_4_10_1 doi: 10.1016/j.cell.2008.06.049 – ident: e_1_2_4_2_1 doi: 10.1038/nature10600 – ident: e_1_2_4_18_1 doi: 10.1242/jcs.071340 – ident: e_1_2_4_13_1 doi: 10.1158/0008-5472.CAN-06-3452 – ident: e_1_2_4_12_1 doi: 10.1016/j.cell.2008.03.039 – ident: e_1_2_4_19_1 doi: 10.1111/j.1474-9726.2010.00608.x – ident: e_1_2_4_8_1 doi: 10.1667/RR1658.1 – ident: e_1_2_4_9_1 doi: 10.1091/mbc.E07-03-0280 – ident: e_1_2_4_17_1 doi: 10.1038/nrc2603 – ident: e_1_2_4_14_1 doi: 10.1089/rej.2007.0628 – ident: e_1_2_4_3_1 doi: 10.1158/0008-5472.CAN-05-1716 – ident: e_1_2_4_15_1 doi: 10.4161/cc.8.20.9857 – ident: e_1_2_4_21_1 doi: 10.18632/aging.100196 – ident: e_1_2_4_4_1 doi: 10.1038/nrm2233 |
| SSID | ssj0017903 |
| Score | 2.5762303 |
| Snippet | Summary
Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen... Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen species... Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen... |
| SourceID | pubmedcentral proquest crossref pubmed wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 345 |
| SubjectTerms | 53BP1 aging Bystander Effect Cell Line cell signalling Cellular Senescence Coculture Techniques DNA Damage fluorescence GFP Hepatocytes - cytology Hepatocytes - metabolism Humans Original Reactive Oxygen Species - metabolism Rodents Senescence |
| SummonAdditionalLinks | – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dS8MwEA-iCL6I31an9MHXjDWfjSA6xkREfXKwt9AmKQpSdZvg_nvv2m1ubKBvpflo-rtr8rvkekfIhWIseK8lLUyQVDjHqQm5otIz5zMeiqSKpff4pO564r4v-2tk-rviBMDhStMO80n1Bm_N78_xNXzwV3NeOUILajRDnwPc3GtpI5vALDeY4AL1_lH8ni1o0-KLPj0rWy8uVEvsc9mJcp7cVqvT7Q7ZntDKuF3rwS5ZC-Ue2awTTY73yU07HuKkhr3EuFcf5-NqEyEM4tqj43JWwQUKdjpI3M_dOiDPt93nzh2d5E6gToINQLM0LTDxJebry53iBfMt7ZIkT7xpycIDcXFO6UxjRHnjTO61lqoQUjMPixY_JOvlexmOSZxDfyoNLHWpFDC_ZUmuM2kcMC0tTZFFJJniZD_qCBl23rLQwiK2FrG1Fbb2OyKNKaB2KnKLcYEwMyPnEYlnxaDtCEtWhvevoTV4LgpGIlQ5quGfPRN4DkuUYhHRC4KZVcBA2osl5etLFVCbwyzGDLRUlQj__Rq23ek-wNXJ3-M9JVvYsvb5aZD10eArnAGdGeXnlXb-ADEZ7cY priority: 102 providerName: Scholars Portal – databaseName: Wiley Online Library - Core collection (SURFmarket) dbid: DR2 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bS8MwFA4iCL54v8wbffC1Y02bpPFtjo0h6oMo7C00l-IYVFk3UJ_8Cf5Gf4k5SVe26YOIbyW3NufkJF-S0-8gdE4xNlozEubckDBRKg65kTQkGiudxSaPHJfezS3tPyRXAzKo_J_gXxjPD1EfuIFluPkaDDyT5ZKRsyTkDIOnARzptRgnTcCTwKsH-OiuZpICHirna--rROmiU8-PDS2uVN_g53cvynl065an3iYazTrmvVJGzelENtXbEufj__R8C21UKDZo-2G3jVZMsYPWfFzL11102Q5KmEPhmwO4GgjkqzuzMOPAO5Bc1AWU-Xz_GBbaDjE9l7iH7nvd-04_rII1hIrYTUeYpWkOkTYhQKBUNM6xbjEVRTLSvEVybZGSUpRlDCjsueJSM0ZonhCGtV0l4320WjwV5hAF0rZHU4NTlZLETqhZJFlGuLLQjhGeZw0UzfQinj0lh5jfyrBEgGgEiEY40YiXBjqZKVBURloKICKCUJBx3EBBnW3NCwSTFeZpWgoOF7F2V2qLHHh11--0wApHlOIGYgsDoS4AzN2LOcXw0TF4x3baxNzWpE7Pv-6GaHe61_bp6K8Vj9E6JHvXoxO0OhlPzalFVRN55uzlC5qpFEA priority: 102 providerName: Wiley-Blackwell |
| Title | A senescent cell bystander effect: senescence‐induced senescence |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1474-9726.2012.00795.x https://www.ncbi.nlm.nih.gov/pubmed/22321662 https://www.proquest.com/docview/1544769333/abstract/ https://search.proquest.com/docview/928908283 https://pubmed.ncbi.nlm.nih.gov/PMC3488292 |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dSxwxEB88oeBLqba2Wz_Yh77Gu83nxieP00OlV6RY8C1sPpYKuoqnoP-9k-zucYcv4ktYkpBkZ2YzM8lvZwB-SUqD90qQWgdBuHOM6GAlEZ46X7FQFymW3uyPPP3Hz6_E1RqI_l-YBNp39vqgubk9aK7_J2zl_a0b9jix4cVswlDqqKbDAQwUY72L3l0dKJ3SIRdccaJx512F77S1NIIT4ingSGmRYlGjlqSFlHRVPb2xOd9CJ5dN2qSTpl_gc2dM5uN20ZuwFpot-NSml3z5CkfjfB63sjhKHk_oc_uSjg7CQ97iOA4XHVwg6J0jn_1S1Te4nJ5cTk5JlzGBOIGWP6nKso7pLmOWPuskq6kfKVcUtvB6JGqP5opzUlUqxpHXTluvlJA1F4p6VFVsG9abuyb8gNzieLIMtHSl4LirVYVVldAO7SsldF1lUPR0MvdtXAyz7E8obiKZTSSzSWQ2zxns9gQ13ZcyNzEaUMzHyFgG-aIZZTySpWrC3dPc6Hgbiq4hdvnekn8xZ8-3DNQKYxYdYvjs1RaUqhRGu5OiDGRi4btfw4wnJ7_x6eeHp9yBjThgCwDahfXHh6ewh7bNo92HAeUXWB7_pVhOz86xnPFyP8n4K1qC9bg |
| link.rule.ids | 230,315,733,786,790,891,1382,2236,11589,24346,27957,27958,46087,46329,46511,46753,50849,50958,53827,53829 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NT9swFH8CpgkubOyLbHzkwNVt48R2vNOqCtSNFnHoJm5W_BGBNgKirQT76_fsJFU7LsAtsi07zu89-z37l_cAjjilzlrBSCkdI5kxKZFOc8IsNbZIXZmEWHrjMz78mf24YBdrwNp_YQJp3-irTvXnulNdXQZu5e216bY8se75eJCi1FFJu-vwCvWVitZJby4PhAwJkZNMZETi2rtK4KlLqacn-HPAnpAsRKPGfZImnNPVDeqR1fmYPLls1IZd6eQN_GrnU5NRfnfmM90xf_8L9fjsCb-F7cZOjft19Q6sueodvK4zVz68h2_9eOpXSf96sT_8j_VDOJVwd3FNEfm6aGAcQccfRcguFX2AycnxZDAkTTIGYhg6FaTI89Jn0vQJALXhaUltT5gk0YmVPVZatISM4aIQPkS9NFJbIRgvMyaoxV0w_Qgb1U3ldiHW2B_PHc1NzjJcMItEi4JJg6abYLIsIkhaANRtHXJDLbsqIlMeP-XxUwE_dR_BXouUapRwqnygIZ_qMU0jiBfVqD7-sxSVu5lPlfQXreh1YpNPNa6LMVuBiECsIL5o4CNzr9YgfiFCd4NXBDzIxpOnofqD4xE-fX7xkIewOZyMR2r0_ez0C2z5zmue0R5szO7mbh9NqJk-CArzDxuhFC8 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB4VqiIu9A2hPHLo1bsbJ7bjnlhtWVFe4gAS4mLFj6irlrBidyXg13fsJKvdckHcImdkx_lm7Bn70wzAd06ps1YwUkrHSGZMSqTTnDBLjS1SVyYhl97ZOT-6yo6v2fVCqa9A2jd61Kn-3naq0e_ArRzfmm7LE-tenA1S1DoqaXdsy-4KvEWbpbIN1JsLBCFDUeQkExmRuP4uk3jqVuopCv4ssCckCxmpca-kCed0eZN65nk-J1AuOrZhZxq-h5t2TjUh5U9nNtUd8_RfusdXTfoDbDT-atyvRT7CG1d9gnd1BcvHz3DQjyd-tfSfGPtLgFg_htMJdx_XVJEfcwHjyKiyqEp2oekLXA4PLwdHpCnKQAzD4IIUeV76ipq-EKA2PC2p7QmTJDqxssdKix6RMVwUwqeql0ZqKwTjZcYEtbgbpl9htbqr3BbEGvvjuaO5yVmGC2eRaFEwadCFE0yWRQRJC4Ia16k31GLIIjLlMVQeQxUwVA8R7LRoqcYYJ8onHPIlH9M0gnj-Gs3I_5aicneziZL-whWjTxTZrLGdj9kqRQRiCfW5gM_QvfwGMQyZuhvMIuBBP148DdUfHJ7i0_arh9yHtYufQ3X66_zkG6z7vmu60Q6sTu9nbhc9qaneCzbzD_piFq8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+senescent+cell+bystander+effect%3A+senescence-induced+senescence&rft.jtitle=Aging+cell&rft.au=Nelson%2C+Glyn&rft.au=Wordsworth%2C+James&rft.au=Wang%2C+Chunfang&rft.au=Jurk%2C+Diana&rft.date=2012-04-01&rft.eissn=1474-9726&rft.volume=11&rft.issue=2&rft.spage=345&rft.epage=349&rft_id=info:doi/10.1111%2Fj.1474-9726.2012.00795.x&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1474-9718&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1474-9718&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1474-9718&client=summon |