A senescent cell bystander effect: senescence‐induced senescence
Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell grow...
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Published in | Aging cell Vol. 11; no. 2; pp. 345 - 349 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.04.2012
John Wiley & Sons, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Summary
Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells have on their normal, proliferation‐competent counterparts. We show here that senescent cells induce a DNA damage response, characteristic for senescence, in neighbouring cells via gap junction‐mediated cell–cell contact and processes involving ROS. Continuous exposure to senescent cells induced cell senescence in intact bystander fibroblasts. Hepatocytes bearing senescence markers clustered together in mice livers. Thus, senescent cells can induce a bystander effect, spreading senescence towards their neighbours in vitro and, possibly, in vivo. |
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Bibliography: | http://wileyonlinelibrary.com/onlineopen#onlineopen_Terms These authors contributed equally to this work. Re‐use of this article is permitted in accordance with the Terms and Conditions set out at ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1474-9718 1474-9726 |
DOI: | 10.1111/j.1474-9726.2012.00795.x |