Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection

• Published in: Microbiology and immunology Vol. 56; no. 3; p. 171
• Main Authors: Sugamata, Ryuichi, Dobashi, Hideki, Nagao, Tomokazu, Yamamoto, Ki-Ichi, Nakajima, Noriko, Sato, Yuko, Aratani, Yasuaki, Oshima, Masamichi, Sata, Tetsutaro, Kobayashi, Kazuo, Kawachi, Shoji, Nakayama, Toshinori, Suzuki, Kazuo
• Format: Journal Article
• Language: English
• Published: Australia 01.03.2012
• Subjects: Animals; Cytokines - secretion; Female; Influenza A Virus, H1N1 Subtype - pathogenicity; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils - immunology; Orthomyxoviridae Infections - pathology; Peroxidase - deficiency; Peroxidase - metabolism; Pneumonia, Viral - pathology; Respiratory Distress Syndrome, Adult - pathology
• ISSN: 1348-0421
• DOI: 10.1111/j.1348-0421.2011.00424.x

Because the pathogenesis of acute respiratory distress syndrome (ARDS) induced by influenza virus infection remains unknown, we can only improve on existing therapeutic interventions. To approach the subject, we investigated immunological etiology focused on cytokines and an acute lung damage factor...