Extracellular matrix in the CNS induced by neuropathogenic viral infection

• Published in: Neuropathology Vol. 37; no. 4; pp. 311 - 320
• Main Authors: Watanabe, Rihito, Kakizaki, Masatoshi
• Format: Journal Article
• Language: English
• Published: Australia Wiley 01.08.2017; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Subjects: Animals; Antigens; astrocyte; Astrocytes; Astrocytes - pathology; Brain; Brain - pathology; Central nervous system; Collagen; Collagen (type III); Coronaviridae; coronavirus; Coronavirus Infections; Coronavirus Infections - pathology; Coronaviruses; Extracellular Matrix; Extracellular Matrix - pathology; Fibers; fibroblastic reticular cell; Infections; Laminin; Leukocytes; Lymph nodes; Meninges; Mice; Mice, Inbred BALB C; Murine hepatitis virus; Murine hepatitis virus - pathogenicity; Neuropathology; Neurovirulence; Nursing; Original; Parenchyma; Spleen; Ventricle; Ventricles (cerebral); Viral infections; Virulence; collagen; coronavirus; laminin; astrocyte; fibroblastic reticular cell

During the early phase of infection with an extremely neurovirulent murine coronavirus, cl‐2, the ER‐TR7 antigen (ERag)‐positive fibers (ERfibs) associated with laminin and collagen III show a rapid increase in expression levels in the meninges, followed by an appearance of the antigens in the ventr...