Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase

• Published in: FEBS open bio Vol. 11; no. 12; pp. 3262 - 3275
• Main Authors: Monturiol‐Gross, Laura, Villalta‐Romero, Fabian, Flores‐Díaz, Marietta, Alape‐Girón, Alberto
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2021; John Wiley and Sons Inc; Wiley
• Subjects: active sites; Amino acids; Animal models; Animals; Bacteria; bacterial pathogenesis; bacterial phospholipases; bacterial sphingomyelinases; bacterial toxins; Binding sites; Cell culture; Clostridium perfringens; Clostridium perfringens - enzymology; Clostridium perfringens - pathogenicity; computer simulation; Enzymes; Gangrene; Humans; Infections; Infectious diseases; Kinases; Lipids; Listeria; Listeria monocytogenes; Listeria monocytogenes - enzymology; Listeria monocytogenes - pathogenicity; mechanism of action; pathogenesis; Phosphatase; Phospholipases; Pseudomonas aeruginosa; Pseudomonas aeruginosa - enzymology; Pseudomonas aeruginosa - pathogenicity; Review; Reviews; Sphingomyelin phosphodiesterase; Sphingomyelin Phosphodiesterase - metabolism; Sphingomyelin Phosphodiesterase - physiology; Sphingomyelinase C; Substrate specificity; Type C Phospholipases - genetics; Type C Phospholipases - metabolism; Type C Phospholipases - physiology; Virulence; Virulence factors; bacterial sphingomyelinases; bacterial phospholipases; bacterial pathogenesis; bacterial toxins; virulence factors

Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles as virulence factors in several human and animal infectious diseases. Some bacterial phospholipases C (PLCs) have both phosphatidylcholinest...