A newly identified mechanism involved in regulation of human mesenchymal stem cells by fibrous substrate stiffness

• Published in: Acta biomaterialia Vol. 42; pp. 247 - 257
• Main Authors: Yuan, Huihua, Zhou, Yaxian, Lee, Ming-Song, Zhang, Yanzhong, Li, Wan-Ju
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.09.2016
• Subjects: Alignment; Annealing; Biomarkers - metabolism; Biomedical materials; Cell Lineage - drug effects; Cell Proliferation - drug effects; Cell Shape - drug effects; Control; Cytoskeleton - drug effects; Cytoskeleton - metabolism; Differentiation; Electrospun fiber; Gene expression; Humans; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors; Mesenchymal stem cell; Mesenchymal Stromal Cells - cytology; Osteogenesis - drug effects; Polyesters - chemistry; Polyesters - pharmacology; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stiffness; Substrates; Mesenchymal stem cell; Macrophage migration inhibitory factor; Stiffness; Differentiation; Electrospun fiber

[Display omitted] Stiffness of biomaterial substrates plays a critical role in regulation of cell behavior. Although the effect of substrate stiffness on cell behavior has been extensively studied, molecular mechanisms of regulation rather than those involving cytoskeletal activities still remain el...