Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling

• Published in: Heliyon Vol. 3; no. 5; p. e00309
• Main Authors: Stojadinovic, Olivera, Wikramanayake, Tongyu C., Villasante Fricke, Alexandra C., Yin, Natalie C., Liang, Liang, Hinde, Eleanor, Escandon, Julia, Tomic-Canic, Marjana, Ansell, David M., Paus, Ralf, Jimenez, Joaquin J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2017; Elsevier
• Subjects: alopecia; animal models; drug therapy; gene expression; interleukin-1beta; Medicine; morphogenesis; neutralization; Medicine
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2017.e00309

Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be ma...