Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

• Published in: EBioMedicine Vol. 47; pp. 529 - 542
• Main Authors: Nagpal, Ravinder, Neth, Bryan J., Wang, Shaohua, Craft, Suzanne, Yadav, Hariom
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2019; Elsevier
• Subjects: Advanced Basic Science; Aged; Alzheimer; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer Disease - psychology; Apolipoprotein E4 - genetics; Apolipoprotein E4 - metabolism; Biomarkers; Cognitive Dysfunction; Dementia; Diet; Diet, Ketogenic; Diet, Mediterranean; Fatty Acids, Volatile - metabolism; Female; Gastrointestinal Microbiome; High fat; Humans; Internal Medicine; Ketogenic; Male; Microbiota; Middle Aged; Nutrition; Research paper; Short-chain fatty acids; Short-chain fatty acids; Lefse; Aß40/42; AD; FFAR 2/3; Nutrition; OTUs; LDA; CN; Alzheimer; Ketogenic; LPS; Microbiota; MCI; Diet; High fat; AHAD; PD; ApoE ε-4; KD; SCFAs; MMKD; Dementia; apolipoprotein-E ε-4 allele; LDA effect size; modified Mediterranean ketogenic diet; ketogenic diet; phylogenetic diversity; American Heart Association Diet; Alzheimer's disease; linear discrimination analysis; mildly cognitive impaired; free fatty acid receptor 2/3; amyloid ß40/42; operational taxonomic units; cognitively normal; lipopolysaccharide

Alzheimer's disease (AD) prevalence is increasing, but its etiology remains elusive. Gut microbes can contribute to AD pathology and may help identifying novel markers and therapies against AD. Herein, we examine how the gut microbiome differs in older adults with mild cognitive impairment comp...