Differential scanning calorimetry as a complementary diagnostic tool for the evaluation of biological samples

• Published in: Biochimica et biophysica acta Vol. 1860; no. 5; pp. 981 - 989
• Main Authors: Garbett, Nichola C., Brock, Guy N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2016
• Subjects: Algorithms; Blood Proteins - chemistry; Calorimetry, Differential Scanning; Case-Control Studies; data collection; Diagnostic classification; Differential scanning calorimetry; Humans; Logistic Models; lupus erythematosus; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; patients; Penalized classification methods; Plasma proteome; Principal Component Analysis; proteome; Proteome - chemistry; Registries; Systemic lupus erythematosus; thermal stability; Thermodynamics; Thermogram; LR; LDA; GLM; SVM-SCAD; SVM; SLE; AUC; Systemic lupus erythematosus; DSC; SCAD; PLS; LASSO; LFRR; Penalized classification methods; TFM; LR-ENET; Cpex; Differential scanning calorimetry; LR-LASSO; ROC; SVM-ESCAD; PLS-DA; Thermogram; PC; Tmax; SPLS-DA; Diagnostic classification; Plasma proteome; LDA-LASSO

Differential scanning calorimetry (DSC) is a tool for measuring the thermal stability profiles of complex molecular interactions in biological fluids. DSC profiles (thermograms) of biofluids provide specific signatures which are being utilized as a new diagnostic approach for characterizing disease...