Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock

• Published in: The Journal of neuroscience Vol. 33; no. 21; pp. 9021 - 9027
• Main Authors: Sakamoto, Kensuke, Norona, Frances E, Alzate-Correa, Diego, Scarberry, Daniel, Hoyt, Kari R, Obrietan, Karl
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 22.05.2013
• Subjects: Animals; Brief Communications; Chromatin Immunoprecipitation; Circadian Clocks - physiology; CREB-Binding Protein - genetics; CREB-Binding Protein - metabolism; Female; HEK293 Cells; Humans; Light; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Period Circadian Proteins - genetics; Period Circadian Proteins - metabolism; Phosphopyruvate Hydratase - metabolism; Photic Stimulation; Suprachiasmatic Nucleus - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transfection; Up-Regulation - physiology; Up-Regulation - radiation effects

The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in circadian physiology has focused on how changes in the phosphorylation state of CREB regulate the timing processes. However, beyond changes in pho...