Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock
The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in circadian physiology has focused on how changes in the phosphorylation state of CREB regulate the timing processes. However, beyond changes in pho...
Saved in:
Published in | The Journal of neuroscience Vol. 33; no. 21; pp. 9021 - 9027 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Society for Neuroscience
22.05.2013
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in circadian physiology has focused on how changes in the phosphorylation state of CREB regulate the timing processes. However, beyond changes in phosphorylation, CREB-dependent transcription can also be regulated by the CREB coactivator CRTC (CREB-regulated transcription coactivator), also known as TORC (transducer of regulated CREB). Here we profiled both the rhythmic and light-evoked regulation of CRTC1 and CRTC2 in the murine suprachiasmatic nucleus (SCN), the locus of the master mammalian clock. Immunohistochemical analysis revealed rhythmic expression of CRTC1 in the SCN. CRTC1 expression was detected throughout the dorsoventral extent of the SCN in the middle of the subjective day, with limited expression during early night, and late night expression levels intermediate between mid-day and early night levels. In contrast to CRTC1, robust expression of CRTC2 was detected during both the subjective day and night. During early and late subjective night, a brief light pulse induced strong nuclear accumulation of CRTC1 in the SCN. In contrast with CRTC1, photic stimulation did not affect the subcellular localization of CRTC2 in the SCN. Additionally, reporter gene profiling and chromatin immunoprecipitation analysis indicated that CRTC1 was associated with CREB in the 5' regulatory region of the period1 gene, and that overexpression of CRTC1 leads to a marked upregulation in period1 transcription. Together, these data raise the prospect that CRTC1 plays a role in fundamental aspects of SCN clock timing and entrainment. |
---|---|
AbstractList | The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in circadian physiology has focused on how changes in the phosphorylation state of CREB regulate the timing processes. However, beyond changes in phosphorylation, CREB-dependent transcription can also be regulated by the CREB coactivator CRTC (CREB-regulated transcription coactivator), also known as TORC (transducer of regulated CREB). Here we profiled both the rhythmic and light-evoked regulation of CRTC1 and CRTC2 in the murine suprachiasmatic nucleus (SCN), the locus of the master mammalian clock. Immunohistochemical analysis revealed rhythmic expression of CRTC1 in the SCN. CRTC1 expression was detected throughout the dorsoventral extent of the SCN in the middle of the subjective day, with limited expression during early night, and late night expression levels intermediate between mid-day and early night levels. In contrast to CRTC1, robust expression of CRTC2 was detected during both the subjective day and night. During early and late subjective night, a brief light pulse induced strong nuclear accumulation of CRTC1 in the SCN. In contrast with CRTC1, photic stimulation did not affect the subcellular localization of CRTC2 in the SCN. Additionally, reporter gene profiling and chromatin immunoprecipitation analysis indicated that CRTC1 was associated with CREB in the 5′ regulatory region of the
period1
gene, and that overexpression of CRTC1 leads to a marked upregulation in
period1
transcription. Together, these data raise the prospect that CRTC1 plays a role in fundamental aspects of SCN clock timing and entrainment. The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in circadian physiology has focused on how changes in the phosphorylation state of CREB regulate the timing processes. However, beyond changes in phosphorylation, CREB-dependent transcription can also be regulated by the CREB coactivator CRTC (CREB-regulated transcription coactivator), also known as TORC (transducer of regulated CREB). Here we profiled both the rhythmic and light-evoked regulation of CRTC1 and CRTC2 in the murine suprachiasmatic nucleus (SCN), the locus of the master mammalian clock. Immunohistochemical analysis revealed rhythmic expression of CRTC1 in the SCN. CRTC1 expression was detected throughout the dorsoventral extent of the SCN in the middle of the subjective day, with limited expression during early night, and late night expression levels intermediate between mid-day and early night levels. In contrast to CRTC1, robust expression of CRTC2 was detected during both the subjective day and night. During early and late subjective night, a brief light pulse induced strong nuclear accumulation of CRTC1 in the SCN. In contrast with CRTC1, photic stimulation did not affect the subcellular localization of CRTC2 in the SCN. Additionally, reporter gene profiling and chromatin immunoprecipitation analysis indicated that CRTC1 was associated with CREB in the 5' regulatory region of the period1 gene, and that overexpression of CRTC1 leads to a marked upregulation in period1 transcription. Together, these data raise the prospect that CRTC1 plays a role in fundamental aspects of SCN clock timing and entrainment. |
Author | Sakamoto, Kensuke Norona, Frances E Obrietan, Karl Scarberry, Daniel Hoyt, Kari R Alzate-Correa, Diego |
Author_xml | – sequence: 1 givenname: Kensuke surname: Sakamoto fullname: Sakamoto, Kensuke organization: Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA – sequence: 2 givenname: Frances E surname: Norona fullname: Norona, Frances E – sequence: 3 givenname: Diego surname: Alzate-Correa fullname: Alzate-Correa, Diego – sequence: 4 givenname: Daniel surname: Scarberry fullname: Scarberry, Daniel – sequence: 5 givenname: Kari R surname: Hoyt fullname: Hoyt, Kari R – sequence: 6 givenname: Karl surname: Obrietan fullname: Obrietan, Karl |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23699513$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkU1v1DAQhi1URLeFv1D5yCWLv51ckCBaoKiiUlnO1tSZ7Lpk7cVOKvHvSWip4MZprHk_NNZzRk5iikjIBWdrroV8cxdxyqn4sFaCiYqLtWBcPiOrWW0qoRg_ISsmLKuMsuqUnJVyxxizjNsX5FRI0zSayxVx7ZD8dwqxo0PY7UeacTcNMIYUaerpuEfa3mzeU5_Aj-EexpTnxbblNMTfapmOGfw-QDnMKU99yB66AJH6pfkled7DUPDV4zwn2w-bbfupurr-eNm-u6q8NmaskPGmFuC7BmtT173qde2N5Ir1tme6Y51Fg7pWGuYXari1gB23HG0HnZHn5O1D7XG6PWDnMY4ZBnfM4QD5p0sQ3L9KDHu3S_dOWqWZkHPB68eCnH5MWEZ3CMXjMEDENBXHtebLPc1_WKXWyuqGL1bzYPUzq5Kxf7qIM7dwdJ-_bL7dXH9tL93C0XHhFo5z8OLv_zzF_oCTvwBUs54Y |
CitedBy_id | crossref_primary_10_1016_j_nlm_2019_107084 crossref_primary_10_1152_ajpcell_00319_2013 crossref_primary_10_1007_s13131_017_1101_4 crossref_primary_10_1016_j_molimm_2017_08_006 crossref_primary_10_1038_nn_4010 crossref_primary_10_3389_fnmol_2022_810641 crossref_primary_10_1007_s12079_023_00730_5 crossref_primary_10_1002_pmic_201900257 crossref_primary_10_1038_srep32113 crossref_primary_10_1186_s12915_020_00886_1 crossref_primary_10_1016_j_bbagrm_2018_01_021 crossref_primary_10_1038_s41598_021_01178_6 crossref_primary_10_1080_07420528_2019_1579734 crossref_primary_10_1016_j_sleep_2017_04_008 crossref_primary_10_1038_s41398_017_0023_4 crossref_primary_10_3390_ijms25052469 crossref_primary_10_1016_j_neuron_2014_08_049 crossref_primary_10_1038_onc_2015_283 crossref_primary_10_1016_j_neuron_2019_08_007 crossref_primary_10_1515_mr_2022_0021 crossref_primary_10_3389_fmolb_2021_681696 crossref_primary_10_1038_s41583_018_0026_z crossref_primary_10_1016_j_trecan_2018_12_002 crossref_primary_10_1073_pnas_1620483114 crossref_primary_10_1213_ANE_0000000000000991 crossref_primary_10_1101_cshperspect_a027706 crossref_primary_10_1016_j_tig_2017_03_002 crossref_primary_10_1016_j_tins_2017_10_002 crossref_primary_10_1016_j_mce_2015_07_021 crossref_primary_10_1111_jne_12125 crossref_primary_10_1111_jne_12920 crossref_primary_10_1007_s00018_016_2378_8 crossref_primary_10_1177_0748730418791713 crossref_primary_10_1016_j_neuroscience_2016_01_059 crossref_primary_10_3390_ijms20092363 crossref_primary_10_1152_physrev_00023_2022 |
Cites_doi | 10.1146/annurev-physiol-021909-135919 10.1146/annurev-physiol-021909-135821 10.1074/jbc.274.25.17748 10.1016/S0896-6273(02)00656-6 10.1016/j.cell.2004.09.015 10.1073/pnas.0808749106 10.1038/nrm3072 10.1126/science.1152506 10.1177/0748730410381229 10.1523/JNEUROSCI.2296-08.2009 10.1016/j.mcn.2008.03.005 10.1016/0006-8993(91)91396-I 10.1073/pnas.92.23.10521 10.1038/emboj.2010.235 10.1111/j.1742-4658.2007.05889.x 10.1371/journal.pone.0000016 10.1016/S0092-8674(00)80495-X 10.1016/S0896-6273(03)00164-8 10.1073/pnas.0607524104 10.1038/nature08111 |
ContentType | Journal Article |
Copyright | Copyright © 2013 the authors 0270-6474/13/339021-07$15.00/0 2013 |
Copyright_xml | – notice: Copyright © 2013 the authors 0270-6474/13/339021-07$15.00/0 2013 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7TK 5PM |
DOI | 10.1523/jneurosci.4202-12.2013 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Neurosciences Abstracts PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Neurosciences Abstracts |
DatabaseTitleList | CrossRef MEDLINE Neurosciences Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1529-2401 |
EndPage | 9027 |
ExternalDocumentID | 10_1523_JNEUROSCI_4202_12_2013 23699513 |
Genre | Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NINDS NIH HHS grantid: NS067409 – fundername: NIMH NIH HHS grantid: R01 MH062335 – fundername: NINDS NIH HHS grantid: R01 NS066345 – fundername: NINDS NIH HHS grantid: P30 NS045758 – fundername: NINDS NIH HHS grantid: R01 NS067409 – fundername: NIMH NIH HHS grantid: MH62335 |
GroupedDBID | --- -DZ -~X .55 18M 2WC 34G 39C 53G 5GY 5RE 5VS AAFWJ ABBAR ABIVO ACGUR ACNCT ADBBV ADCOW AENEX AFCFT AFHIN AFOSN AHWXS AIZTS ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P GX1 H13 HYE H~9 KQ8 L7B MVM NPM OK1 P0W P2P QZG R.V RHF RHI RPM TFN TR2 W8F WH7 WOQ X7M XJT YBU YHG YKV YNH YSK AAYXX CITATION 7X8 AETEA 7TK 5PM |
ID | FETCH-LOGICAL-c566t-e01982acd9e8688f4f58c63140f7f05d0d7e6e5845ad7ee5ab7aed171e7dad63 |
IEDL.DBID | RPM |
ISSN | 0270-6474 1529-2401 |
IngestDate | Tue Sep 17 21:28:06 EDT 2024 Sat Aug 17 00:23:43 EDT 2024 Thu Jul 25 10:41:51 EDT 2024 Thu Sep 26 18:06:11 EDT 2024 Sat Sep 28 08:38:42 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 21 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c566t-e01982acd9e8688f4f58c63140f7f05d0d7e6e5845ad7ee5ab7aed171e7dad63 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: K.S., D.A.-C., and K.O. designed research; K.S., F.E.N., D.A.-C., D.S., and K.O. performed research; K.R.H. contributed unpublished reagents/analytic tools; K.S., F.E.N., D.A.-C., K.R.H., and K.O. analyzed data; K.S., D.A.-C., K.R.H., and K.O. wrote the paper. |
OpenAccessLink | https://www.jneurosci.org/content/jneuro/33/21/9021.full.pdf |
PMID | 23699513 |
PQID | 1355475913 |
PQPubID | 23479 |
PageCount | 7 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3745023 proquest_miscellaneous_1551631493 proquest_miscellaneous_1355475913 crossref_primary_10_1523_JNEUROSCI_4202_12_2013 pubmed_primary_23699513 |
PublicationCentury | 2000 |
PublicationDate | 2013-May-22 2013-05-22 20130522 |
PublicationDateYYYYMMDD | 2013-05-22 |
PublicationDate_xml | – month: 05 year: 2013 text: 2013-May-22 day: 22 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of neuroscience |
PublicationTitleAlternate | J Neurosci |
PublicationYear | 2013 |
Publisher | Society for Neuroscience |
Publisher_xml | – name: Society for Neuroscience |
References | 2023041304043225000_33.21.9021.20 2023041304043225000_33.21.9021.7 2023041304043225000_33.21.9021.17 2023041304043225000_33.21.9021.8 2023041304043225000_33.21.9021.16 2023041304043225000_33.21.9021.5 2023041304043225000_33.21.9021.15 2023041304043225000_33.21.9021.6 2023041304043225000_33.21.9021.14 2023041304043225000_33.21.9021.3 2023041304043225000_33.21.9021.13 2023041304043225000_33.21.9021.4 2023041304043225000_33.21.9021.12 2023041304043225000_33.21.9021.1 2023041304043225000_33.21.9021.11 2023041304043225000_33.21.9021.2 2023041304043225000_33.21.9021.10 2023041304043225000_33.21.9021.9 2023041304043225000_33.21.9021.19 2023041304043225000_33.21.9021.18 |
References_xml | – ident: 2023041304043225000_33.21.9021.19 doi: 10.1146/annurev-physiol-021909-135919 – ident: 2023041304043225000_33.21.9021.6 doi: 10.1146/annurev-physiol-021909-135821 – ident: 2023041304043225000_33.21.9021.13 doi: 10.1074/jbc.274.25.17748 – ident: 2023041304043225000_33.21.9021.7 doi: 10.1016/S0896-6273(02)00656-6 – ident: 2023041304043225000_33.21.9021.16 doi: 10.1016/j.cell.2004.09.015 – ident: 2023041304043225000_33.21.9021.4 doi: 10.1073/pnas.0808749106 – ident: 2023041304043225000_33.21.9021.2 doi: 10.1038/nrm3072 – ident: 2023041304043225000_33.21.9021.14 doi: 10.1126/science.1152506 – ident: 2023041304043225000_33.21.9021.11 doi: 10.1177/0748730410381229 – ident: 2023041304043225000_33.21.9021.12 doi: 10.1523/JNEUROSCI.2296-08.2009 – ident: 2023041304043225000_33.21.9021.5 doi: 10.1016/j.mcn.2008.03.005 – ident: 2023041304043225000_33.21.9021.15 doi: 10.1016/0006-8993(91)91396-I – ident: 2023041304043225000_33.21.9021.3 doi: 10.1073/pnas.92.23.10521 – ident: 2023041304043225000_33.21.9021.9 doi: 10.1038/emboj.2010.235 – ident: 2023041304043225000_33.21.9021.17 doi: 10.1111/j.1742-4658.2007.05889.x – ident: 2023041304043225000_33.21.9021.20 doi: 10.1371/journal.pone.0000016 – ident: 2023041304043225000_33.21.9021.1 doi: 10.1016/S0092-8674(00)80495-X – ident: 2023041304043225000_33.21.9021.8 doi: 10.1016/S0896-6273(03)00164-8 – ident: 2023041304043225000_33.21.9021.10 doi: 10.1073/pnas.0607524104 – ident: 2023041304043225000_33.21.9021.18 doi: 10.1038/nature08111 |
SSID | ssj0007017 |
Score | 2.3444273 |
Snippet | The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 9021 |
SubjectTerms | Animals Brief Communications Chromatin Immunoprecipitation Circadian Clocks - physiology CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Female HEK293 Cells Humans Light Male Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Phosphopyruvate Hydratase - metabolism Photic Stimulation Suprachiasmatic Nucleus - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transfection Up-Regulation - physiology Up-Regulation - radiation effects |
Title | Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock |
URI | https://www.ncbi.nlm.nih.gov/pubmed/23699513 https://search.proquest.com/docview/1355475913 https://search.proquest.com/docview/1551631493 https://pubmed.ncbi.nlm.nih.gov/PMC3745023 |
Volume | 33 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bT9swGLUoT3uZxtilgyFPQrylTeJb8sgiEGOAGHQSb5avImJ1EbRI_Hs-u0m1btIe9hbFjpP4fIrPib8LQvvce26cqTLuC59RblVWa-4yA9w7Z0ZTm0onnF_wk5_09IbdbCDWx8Ikp32j21H4NR2F9jb5Vt5Pzbj3ExtfnjdEUBbz8wzQQBDSS_Tu8yvyVGYX5BboIipoFxYMgmt8ehHd466bbyNappoe0bUrVtIpCa-BapD1xekvxvmn4-RvK9HxG_S6o5D4cPmoW2jDhbdo-zCAfJ4-4wOcnDrT3_JtJBtYrO6wChafRRmOr5a15wENPPMY2B9uro6-4mYWAxyeogKHE5OmwG1IrdeLGEd126rHlNsVN-2DSekMcBr5HZocH02ak6yrqZAZIG7zzAGlq0plbO0qXlWeelYZTgAYL3zObG6F4w5YCVNw5JjSQjlbiMIJqywn79FmmAX3EWHvC2EIDCQ0o9prZURhKdd5zOjOiB2icT-X8n6ZOUNGxQFAyBUQMgIhi1JGIIboSz_lEow87lyo4GaLR1lEViRY_c8-ccsPXqSGPh-WMK3u2-M7RGINwFWHmGR7vQVsLyXb7mzt039fuYNelamEBsvKchdtzh8W7jMQmbneQ4PvP6q9ZL4v3Pby6Q |
link.rule.ids | 230,315,733,786,790,891,27957,27958,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLXGeIAXGAxGgYGREG9Jc_EleRzRpm60FdoK2pvlqxaNptPWIsGv57OTVOsmIcFbFDuOrGPH58TH34fQR-Yc01YXEXOpiwgzMioVs5EG7p1QrYgJqRMmUzb6Rk7O6fkWov1ZmGDa16qOmx_zuKkvgrfyaq6HvU9s-HVS5ZxQH5_nAXoI8zXjvUjvPsA8CYl2QXCBMiKcdAeDQXINT6beIHdWHcckC1k9vLnL59LJclYC2cg3l6d7nPOudfLWWnT0FH3ve9FaUC7j1VLF-vedAI__3M0d9KRjp_igLX6GtmzzHO0eNKDM57_wJxz8ouFH_C4SFayDl1g2Bo-9wsenbVp7ABovHAZiiavTw8-4WvizEz-9uIcbsyrFdRNKz1b-iNZFLW9C2Fhc1dc6RErAoeUXaHZ0OKtGUZeuIdLACZeRBbZYZFKb0hasKBxxtNAsB8wddwk1ieGWWSA8VMKVpVJxaU3KU8uNNCx_ibabRWNfIexcynUODXFFiXJKap4awlTig8XT3AzQsAdJXLVBOYQXM4CwWCMsPMIizYRHeIA-9FgKmD9-U0Q2drG6EaknXJyWf63jdxOhIyXU2WvxX7-3HzgDxDdGxrqCj9-9WQJ4hzjeHb6v__vJ9-jRaDYZi_Hx9Msb9DgLmTpolGVv0fbyemX3gS8t1bswO_4Avn8T8w |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwGLWgSIgLW6EMq5EQt-xekmMJHbWlHVXtIFVcLK9qVCYzameQ4Nfz2UlGnSJx6C2KHUfWs-P34s_vQ-gTc45pq8uIucxFhBkZVYrZSAP3TqlWxITUCccTtv-dHJ7T8xupvkLQvlZN3P6cxW1zEWIrFzOdDHFiyclxXXBCvT_PwrjkPnoAczavBqHef4R5GpLtgugCdUQ46Q8Hg-xKDic-SO6sPohJHjJ7-AAvn08nL1gFhKPYXKL-4Z23wydvrEfjJ-jH0JMuDOUyXi1VrP_cMnm8U1efosc9S8W7XZVn6J5tn6Pt3RYU-uw3_oxD3Gj4Ib-NRA3r4SWWrcFHXunj0y69PQCO5w4DwcT16d4XXM_9GYpfXuTDjWmd4aYNpWcrf1TropHXwT4W182VDo4JOLT8Ak3He9N6P-rTNkQauOEyssAay1xqU9mSlaUjjpaaFYC94y6lJjXcMgvEh0q4slQqLq3JeGa5kYYVL9FWO2_tK4Sdy7guoCGuKFFOSc0zQ5hKvWk8LcwIJQNQYtGZcwgvagBlsUZZeJRFlguP8gh9HPAUMI_85ohs7Xx1LTJPvDit_lvH7ypCRyqos9ONgfV7h8EzQnxjdKwreB_vzRLAPPh59xi_vvOTH9DDk69jcXQw-fYGPcpDwg4a5flbtLW8Wtl3QJuW6n2YIH8Ba44Wcw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clock+and+Light+Regulation+of+the+CREB+Coactivator+CRTC1+in+the+Suprachiasmatic+Circadian+Clock&rft.jtitle=The+Journal+of+neuroscience&rft.au=Sakamoto%2C+Kensuke&rft.au=Norona%2C+Frances+E.&rft.au=Alzate-Correa%2C+Diego&rft.au=Scarberry%2C+Daniel&rft.date=2013-05-22&rft.pub=Society+for+Neuroscience&rft.issn=0270-6474&rft.eissn=1529-2401&rft.volume=33&rft.issue=21&rft.spage=9021&rft.epage=9027&rft_id=info:doi/10.1523%2FJNEUROSCI.4202-12.2013&rft_id=info%3Apmid%2F23699513&rft.externalDBID=PMC3745023 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-6474&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-6474&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-6474&client=summon |