Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population

We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral g...

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Published inScientific reports Vol. 8; no. 1; pp. 16727 - 10
Main Authors Oo, Swe Mar, Misu, Hirofumi, Saito, Yoshiro, Tanaka, Mutsumi, Kato, Seiji, Kita, Yuki, Takayama, Hiroaki, Takeshita, Yumie, Kanamori, Takehiro, Nagano, Toru, Nakagen, Masatoshi, Urabe, Takeshi, Matsuyama, Naoto, Kaneko, Shuichi, Takamura, Toshinari
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.11.2018
Nature Publishing Group
Subjects
692/163/2743
692/699/2743
82/1
Blood Glucose - metabolism
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Fasting - blood
Female
Follow-Up Studies
Glucose
Glucose tolerance
Homeostasis
Humanities and Social Sciences
Humans
Hyperglycemia
Hyperglycemia - blood
Hyperglycemia - diagnosis
Insulin
Insulin resistance
Intolerance
Japan
Male
Middle Aged
multidisciplinary
Multivariate analysis
Prognosis
Science
Science (multidisciplinary)
Selenium
Selenium - blood
Selenoprotein P - blood
Japan
Insulinogenic Index
Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR)
Selenoprotein P (SELENOP)
General Japanese Population
Hepatokines
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-018-35067-2

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Abstract We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral glucose tolerance test (OGTT) at baseline and 4-years follow-up. Nine subjects developed either impaired glucose tolerance or type 2 diabetes at follow-up. At baseline, SELENOP concentrations correlated negatively with insulinogenic index, but not with homeostasis model assessment-estimated insulin resistance (HOMA-IR). Multivariate analysis showed that baseline SELENOP predicted fasting plasma glucose at follow-up independently of the other parameters. The receiver operating characteristic (ROC) curve analysis showed that baseline concentrations of serum SELENOP, but not of selenium, were a reliable test to predict future onset of glucose intolerance. In conclusion, elevation of circulating SELENOP, but not of circulating selenium, was positively and independently associated with future onset of glucose intolerance in a general Japanese population.
AbstractList We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral glucose tolerance test (OGTT) at baseline and 4-years follow-up. Nine subjects developed either impaired glucose tolerance or type 2 diabetes at follow-up. At baseline, SELENOP concentrations correlated negatively with insulinogenic index, but not with homeostasis model assessment-estimated insulin resistance (HOMA-IR). Multivariate analysis showed that baseline SELENOP predicted fasting plasma glucose at follow-up independently of the other parameters. The receiver operating characteristic (ROC) curve analysis showed that baseline concentrations of serum SELENOP, but not of selenium, were a reliable test to predict future onset of glucose intolerance. In conclusion, elevation of circulating SELENOP, but not of circulating selenium, was positively and independently associated with future onset of glucose intolerance in a general Japanese population.
We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral glucose tolerance test (OGTT) at baseline and 4-years follow-up. Nine subjects developed either impaired glucose tolerance or type 2 diabetes at follow-up. At baseline, SELENOP concentrations correlated negatively with insulinogenic index, but not with homeostasis model assessment-estimated insulin resistance (HOMA-IR). Multivariate analysis showed that baseline SELENOP predicted fasting plasma glucose at follow-up independently of the other parameters. The receiver operating characteristic (ROC) curve analysis showed that baseline concentrations of serum SELENOP, but not of selenium, were a reliable test to predict future onset of glucose intolerance. In conclusion, elevation of circulating SELENOP, but not of circulating selenium, was positively and independently associated with future onset of glucose intolerance in a general Japanese population.We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral glucose tolerance test (OGTT) at baseline and 4-years follow-up. Nine subjects developed either impaired glucose tolerance or type 2 diabetes at follow-up. At baseline, SELENOP concentrations correlated negatively with insulinogenic index, but not with homeostasis model assessment-estimated insulin resistance (HOMA-IR). Multivariate analysis showed that baseline SELENOP predicted fasting plasma glucose at follow-up independently of the other parameters. The receiver operating characteristic (ROC) curve analysis showed that baseline concentrations of serum SELENOP, but not of selenium, were a reliable test to predict future onset of glucose intolerance. In conclusion, elevation of circulating SELENOP, but not of circulating selenium, was positively and independently associated with future onset of glucose intolerance in a general Japanese population.
ArticleNumber 16727
Author Oo, Swe Mar
Kita, Yuki
Takeshita, Yumie
Nakagen, Masatoshi
Takamura, Toshinari
Takayama, Hiroaki
Kanamori, Takehiro
Misu, Hirofumi
Urabe, Takeshi
Matsuyama, Naoto
Kato, Seiji
Saito, Yoshiro
Tanaka, Mutsumi
Nagano, Toru
Kaneko, Shuichi
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  surname: Misu
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  organization: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, PRESTO, Japan Science and Technology Agency
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  givenname: Yoshiro
  orcidid: 0000-0002-0559-5889
  surname: Saito
  fullname: Saito, Yoshiro
  organization: Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University
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  givenname: Mutsumi
  surname: Tanaka
  fullname: Tanaka, Mutsumi
  organization: Diagnostic R&D, R&D Headquarters, Alfresa Pharma Corporation
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  surname: Kato
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  organization: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
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  givenname: Hiroaki
  surname: Takayama
  fullname: Takayama, Hiroaki
  organization: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
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  givenname: Yumie
  surname: Takeshita
  fullname: Takeshita, Yumie
  organization: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
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  surname: Kanamori
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  organization: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
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  surname: Nagano
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  organization: Department of Gastroenterology, Public Central Hospital of Matto Ishikawa
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  surname: Nakagen
  fullname: Nakagen, Masatoshi
  organization: Department of Gastroenterology, Public Central Hospital of Matto Ishikawa
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  givenname: Takeshi
  surname: Urabe
  fullname: Urabe, Takeshi
  organization: Department of Gastroenterology, Public Central Hospital of Matto Ishikawa
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  givenname: Naoto
  surname: Matsuyama
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  organization: Diagnostic R&D, R&D Headquarters, Alfresa Pharma Corporation
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  surname: Takamura
  fullname: Takamura, Toshinari
  email: ttakamura@med.kanazawa-u.ac.jp
  organization: Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30425271$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Insulinogenic Index
Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR)
Selenoprotein P (SELENOP)
General Japanese Population
Hepatokines
Language English
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Snippet We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin...
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SubjectTerms 692/163/2743
692/699/2743
82/1
Blood Glucose - metabolism
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Fasting - blood
Female
Follow-Up Studies
Glucose
Glucose tolerance
Homeostasis
Humanities and Social Sciences
Humans
Hyperglycemia
Hyperglycemia - blood
Hyperglycemia - diagnosis
Insulin
Insulin resistance
Intolerance
Japan
Male
Middle Aged
multidisciplinary
Multivariate analysis
Prognosis
Science
Science (multidisciplinary)
Selenium
Selenium - blood
Selenoprotein P - blood
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Title Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population
URI https://link.springer.com/article/10.1038/s41598-018-35067-2
https://www.ncbi.nlm.nih.gov/pubmed/30425271
https://www.proquest.com/docview/2132701953
https://www.proquest.com/docview/2133429894
https://pubmed.ncbi.nlm.nih.gov/PMC6233151
Volume 8
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