Molecular mechanisms of diabetic cardiomyopathy

• Published in: Diabetologia Vol. 57; no. 4; pp. 660 - 671
• Main Authors: Bugger, Heiko, Abel, E. Dale
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2014; Springer; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Cardiology. Vascular system; Cardiomyopathy; Cardiovascular disease; Coronary vessels; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - pathology; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetes. Impaired glucose tolerance; Diabetic Cardiomyopathies - etiology; Diabetic Cardiomyopathies - metabolism; Diabetic Cardiomyopathies - pathology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Heart; Heart failure; Heart Failure - etiology; Heart Failure - metabolism; Heart Failure - pathology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Human Physiology; Humans; Hyperglycemia; Hypertension; Internal Medicine; Ischemia; Kinases; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Mortality; Myocarditis. Cardiomyopathies; Proteins; Review; Heart failure; Animal models; Cardiomyopathy; Fibrosis; Inflammation; Diabetes; Review; Lipotoxicity; Metabolism; Autophagy; Endocrinopathy; Animal model; Diabetes mellitus; Cardiovascular disease; Myocardial disease; Heart disease

In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely reco...