IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells

• Published in: EBioMedicine Vol. 33; pp. 196 - 210
• Main Authors: Liu, Jie, Wang, Wang, Wang, Lei, Chen, Shihao, Tian, Bo, Huang, Kewu, Corrigan, Chris J., Ying, Sun, Wang, Wei, Wang, Chen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2018; Elsevier
• Subjects: Advanced Basic Science; Animals; Cell Adhesion; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells - cytology; Endothelial Cells - metabolism; Humans; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - metabolism; Hypoxia - complications; Hypoxia - metabolism; Hypoxia inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxic pulmonary hypertension; IL-33; Interleukin-1 Receptor-Like 1 Protein - metabolism; Interleukin-33 - metabolism; Internal Medicine; Male; Mice; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - metabolism; Research Paper; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Vascular Remodeling; Hypoxia inducible factor 1; Hypoxic pulmonary hypertension; IL-33; Vascular endothelial growth factor

IL-33 may play a role in the vascular remodelling of hypoxic pulmonary hypertension (PH) but the precise mechanisms are still unclear. We hypothesized that hypoxia promotes expression of IL-33 and its receptor ST2 on vascular endothelial cells, which in turn leads to dysfunction of vascular endothel...