HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer

• Published in: Cell communication and signaling Vol. 16; no. 1; pp. 8 - 10
• Main Authors: Fu, Deyuan, Li, Jing, Wei, Jinli, Zhang, Zhengquan, Luo, Yulin, Tan, Haosheng, Ren, Chuanli
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.02.2018; BioMed Central; BMC
• Subjects: Analysis; Animals; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Proliferation; Chromosomal proteins; Female; Fructose-Bisphosphatase - metabolism; Glucose metabolism; Glycolysis; HMGB2; HMGB2 Protein - antagonists & inhibitors; HMGB2 Protein - genetics; HMGB2 Protein - metabolism; Humans; Lactate Dehydrogenases - metabolism; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Prognosis; Proliferation; Proportional Hazards Models; RNA Interference; RNA, Small Interfering - metabolism; Survival Rate; Warburg effect; HMGB2; Breast cancer; Proliferation; Warburg effect

High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown. We investigated HMGB2 expression in 185 cases of primary breast cancer and matched normal breast tissue speci...