Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir

• Published in: Amino acids Vol. 47; no. 9; pp. 1961 - 1974
• Main Authors: Schneider, Jessica Y, Rothmann, Sabine, Schröder, Frank, Langen, Jennifer, Lücke, Thomas, Mariotti, François, Huneau, Jean François, Frölich, Jürgen C, Tsikas, Dimitrios
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.09.2015; Springer Nature B.V; Springer Verlag
• Subjects: absorption; Adult; Aged; Analytical Chemistry; Arginine; Arginine - administration & dosage; Arginine and Relatives; Autoxidation; Biochemical Engineering; Biochemistry; Biological activity; Biomedical and Life Sciences; body weight; carbonate dehydratase; Carbonic anhydrase; Cardiovascular disease; Children; Computer aided design; Coronary artery disease; Coronary vessels; Dietary supplements; Double-Blind Method; elderly; Excretion; Female; Guanidine; Heart diseases; Homoarginine; Humans; Intravenous administration; Intravenous infusion; intravenous injection; Kidney Tubules, Proximal - metabolism; Life Sciences; long term effects; Male; Middle Aged; Neurobiology; Nitrates - urine; Nitric oxide; Nitric Oxide - urine; Nitric-oxide synthase; Nitrites; Nitrites - urine; Original Article; Patients; Peripheral Arterial Disease - drug therapy; Peripheral Arterial Disease - urine; Placebos; Prostacyclin; Proteomics; Reabsorption; Renal function; Reservoirs; Synthesis; Urine; Vein & artery diseases; Cardiovascular disease; Prostacyclin; Nitrite; Thromboxane; Renal carbonic anhydrase; Nitric oxide; EXCRETORY NITRITE; CARBONIC-ANHYDRASE; OXIDATIVE STRESS; DEPENDENT VASODILATION; NITRATE; HEALTHY-SUBJECTS; ASYMMETRIC DIMETHYLARGININE; URINARY-EXCRETION; OXIDE SYNTHESIS; CHROMATOGRAPHY MASS-SPECTROMETRY

Despite saturation of nitric oxide (NO) synthase (NOS) by its substrate L-arginine (Arg), oral and intravenous supplementation of Arg may enhance NO synthesis, a phenomenon known as “The L-arginine paradox”. Yet, Arg is not only a source of NO, but is also a source for guanidine-methylated (N ᴳ) arg...