Human Embryonic Stem Cell–derived Neural Crest Cells Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats

• Published in: Cell transplantation Vol. 30; p. 963689720988245
• Main Authors: Jones, Iwan, Novikova, Liudmila N., Wiberg, Mikael, Carlsson, Leif, Novikov, Lev N.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Animals; Axonogenesis; Biological activity; Cell Differentiation; Dorsal root ganglia; Female; hESCs; Human Embryonic Stem Cells - metabolism; Humans; motor recovery; Neural crest; Neural Crest - metabolism; neural crest cells; Neural stem cells; Original; Quality of life; Rats; Rats, Sprague-Dawley; Recovery of Function - physiology; Sensorimotor system; Spinal cord injuries; Spinal Cord Injuries - pathology; Spinal Cord Injuries - therapy; spinal cord injury; Stem cells; Transplantation; Trophic factors; vertical cylinder test; spinal cord injury; vertical cylinder test; neural crest cells; hESCs; transplantation; motor recovery

Spinal cord injury results in irreversible tissue damage and permanent sensorimotor impairment. The development of novel therapeutic strategies that improve the life quality of affected individuals is therefore of paramount importance. Cell transplantation is a promising approach for spinal cord inj...