Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development

• Published in: The Journal of neuroscience Vol. 36; no. 21; pp. 5820 - 5832
• Main Authors: Harris, Kathryn P, Akbergenova, Yulia, Cho, Richard W, Baas-Thomas, Maximilien S, Littleton, J Troy
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 25.05.2016
• Subjects: Animals; Animals, Genetically Modified; Axon Guidance - physiology; Drosophila; Drosophila - genetics; Gene Expression Regulation, Developmental - physiology; Humans; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurogenesis - physiology; Neuromuscular Junction - physiology; Presynaptic Terminals - physiology; Wnt Signaling Pathway - physiology; Wnt signaling; Shank; postsynaptic scaffold; synaptic development

Prosap/Shank scaffolding proteins regulate the formation, organization, and plasticity of excitatory synapses. Mutations in SHANK family genes are implicated in autism spectrum disorder and other neuropsychiatric conditions. However, the molecular mechanisms underlying Shank function are not fully u...