Assessment of weighted topological overlap (wTO) to improve fidelity of gene co-expression networks

• Published in: BMC bioinformatics Vol. 20; no. 1; pp. 58 - 11
• Main Authors: Voigt, André, Almaas, Eivind
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.01.2019; BioMed Central; BMC
• Subjects: Biological network analysis; Correlation network; Data mining; Developmental biology; Evaluation; Gene co-expression network; Gene expression; Genes; Genetic research; Methods; Weighted topological overlap; Norway; Biological network analysis; Correlation network; Gene co-expression network; Weighted topological overlap

For more than a decade, gene expression data sets have been used as basis for the construction of co-expression networks used in systems biology investigations, leading to many important discoveries in a wide range of subjects spanning human disease to evolution and the development of organisms. A c...