Natural-lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis - Yang, Chunhua; Zhang, Mingzhen; Lama, Sudeep; Wang, Lixin; Merlin, Didier (Journal of controlled release, 2020)
Keywords: 6-shogaol; animal models; Animals; anti-inflammatory activity; anti-inflammatory agents; bioavailability; Caco-2 Cells; Catechols; Colitis - chemically induced; Colitis - drug therapy; Colitis, Ulcerative - drug therapy; Colon; Colon targeted drug delivery; Dextran Sulfate; Disease Models, Animal; drug delivery systems; gene expression regulation; Humans; in vitro studies; interleukin-10; interleukin-1beta; interleukin-6; kidneys; Lipids; liver; macrophages; metabolites; mice; Nanoparticles; Natural-lipid nanoparticles; oral administration; pharmacokinetics; Phase II metabolites; reverse transcriptase polymerase chain reaction; tissue repair; tumor necrosis factor-alpha; ulcerative colitis; Natural-lipid nanoparticles; Colon targeted drug delivery; 6-shogaol; Phase II metabolites