Deficiency and absence of endogenous isoprene in adults, disqualified its putative origin

• Published in: Heliyon Vol. 7; no. 1; p. e05922
• Main Authors: Sukul, Pritam, Richter, Anna, Schubert, Jochen K., Miekisch, Wolfram
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2021; Elsevier
• Subjects: biomarkers; biosynthesis; Breath isoprene; breathing; Breathomics; childbirth; cholesterol; Cholesterol biosynthesis; Disease biomarker; gene expression; hemodynamics; humans; isoprene; mass spectrometry; menstrual cycle; Metabolic disorders; metabolites; metabolomics; Mevalonate pathway; phenotype; pregnancy; PTR-MS; Volatile metabolomics; Disease biomarker; Cholesterol biosynthesis; Mevalonate pathway; Breath isoprene; PTR-MS; Volatile metabolomics; Breathomics; Metabolic disorders

Isoprene (C5H8) is a clinically important breath metabolite. Although, hundreds of studies have reported differential expressions in isoprene exhalation as breath biomarker for diverse diseases, the substance couldn't enter to clinical practice as diagnostic marker. Moreover, many experimental/...