Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model

• Published in: EBioMedicine Vol. 41; pp. 465 - 478
• Main Authors: Nivarthi, Usha K., Tu, Huy A., Delacruz, Matthew J., Swanstrom, Jesica, Patel, Bhumi, Durbin, Anna P., Whitehead, Stephen S., Pierce, Kristen K., Kirkpatrick, Beth D., Baric, Ralph S., Nguyen, Ngan, Emerling, Daniel E., de Silva, Aravinda M., Diehl, Sean A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019; Elsevier
• Subjects: Acute Disease; Advanced Basic Science; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibody; B-Lymphocytes - cytology; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Dengue; Dengue - diagnosis; Dengue - virology; Dengue Virus - genetics; Dengue Virus - isolation & purification; Epitope Mapping; Epitopes - immunology; Humans; Humoral immunity; Internal Medicine; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - virology; Longitudinal Studies; Plasma Cells - cytology; Plasma Cells - metabolism; Research paper; Serogroup; Viral Envelope Proteins - immunology; Viral infection; Antibody; Viral infection; Dengue; Humoral immunity

Acute viral infections induce a rapid and transient increase in antibody-secreting plasmablasts. At convalescence, memory B cells (MBC) and long-lived plasma cells (LLPC) are responsible for long-term humoral immunity. Following an acute viral infection, the specific properties and relationships bet...