Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

• Published in: Frontiers in microbiology Vol. 10; p. 1966
• Main Authors: Turnbull, Kathryn Jane, Dzhygyr, Ievgen, Lindemose, Søren, Hauryliuk, Vasili, Roghanian, Mohammad
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.08.2019
• Subjects: (p)ppGpp; Microbiology; RelA; ribosome; RSH; stringent response; translation; translation; ribosome; (p)ppGpp; RSH; RelA; stringent response

Amino acid starvation in activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp. The alarmone acts as an intercellular messenger to regulate transcription, translation and metabolism to mediate bacterial stress adaptation. The enzym...