In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia

• Published in: Journal of translational medicine Vol. 17; no. 1; pp. 261 - 21
• Main Authors: Al-Rifai, Rida, Nguyen, Philippe, Bouland, Nicole, Terryn, Christine, Kanagaratnam, Lukshe, Poitevin, Gaël, François, Caroline, Boisson-Vidal, Catherine, Sevestre, Marie-Antoinette, Tournois, Claire
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.08.2019; BioMed Central; BMC
• Subjects: Amputation; Angiogenesis; B cells; Biotechnology; Blood flow; Cardiology and cardiovascular system; Care and treatment; Cell therapy; Cellular Biology; Critical limb ischemia; Cytokines; Diagnosis; Endothelial growth factors; Endothelium; Genes; Hematology; Human health and pathology; Ischemia; Life Sciences; Limb salvage; Mesenchymal stem cells; Stem cell research; Stem cell transplantation; Stem cells; Testing; France; Angiogenesis; Cell therapy; Critical limb ischemia; Mesenchymal stem cells

Cell therapy has been proposed for patients with critical limb ischemia (CLI). Autologous bone marrow derived cells (BMCs) have been mostly used, mesenchymal stem cells (MSCs) being an alternative. The aim of this study was to characterize two types of MSCs and evaluate their efficacy. MSCs were obt...