The effects of GluA1 deletion on the hippocampal population code for position

• Published in: The Journal of neuroscience Vol. 32; no. 26; pp. 8952 - 8968
• Main Authors: Resnik, Evgeny, McFarland, James M, Sprengel, Rolf, Sakmann, Bert, Mehta, Mayank R
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 27.06.2012
• Subjects: Action Potentials - genetics; Action Potentials - physiology; Animals; Brain Mapping; Electrodes, Implanted; Hippocampus - cytology; Mice; Mice, Inbred C57BL; Mice, Knockout; Movement - physiology; Neurons - physiology; Receptors, AMPA - deficiency; Reward; Space Perception; Spatial Behavior - physiology

The GluA1 subunit of AMPA receptors (AMPARs) is critical for hippocampal synaptic transmission and plasticity. Here, we measured the activity of single units from the CA1 region of the hippocampus while GluA1 knock-out (GluA1⁻/⁻) and wild-type (WT) mice traversed a linear track. Although overall fir...