Human-Scale Whole-Organ Bioengineering for Liver Transplantation: A Regenerative Medicine Approach

• Published in: Cell transplantation Vol. 22; no. 2; pp. 231 - 242
• Main Authors: Yagi, Hiroshi, Fukumitsu, Ken, Fukuda, Kazumasa, Kitago, Minoru, Shinoda, Masahiro, Obara, Hideaki, Itano, Osamu, Kawachi, Shigeyuki, Tanabe, Minoru, Coudriet, Gina M., Piganelli, Jon D., Gilbert, Thomas W., Soto-Gutierrez, Alejandro, Kitagawa, Yuko
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.02.2013; SAGE Publishing
• Subjects: Animals; Cells, Cultured; Hepatocytes - cytology; Hepatocytes - physiology; Hepatocytes - transplantation; Liver - blood supply; Liver - cytology; Liver - pathology; Liver - physiology; Liver Transplantation - methods; Male; Regenerative Medicine - methods; Swine; Tissue Engineering - methods; Liver tissue engineering; Regenerative medicine; Decellularization; Porcine liver; Bioengineering in organ transplantation; Whole-organ scaffold; Bile duct

At this time, the only definitive treatment of hepatic failure is liver transplantation. However, transplantation has been limited by the severely limited supply of human donor livers. Alternatively, a regenerative medicine approach has been recently proposed in rodents that describe the production...