Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA

• Published in: Diabetologia Vol. 52; no. 7; pp. 1231 - 1239
• Main Authors: Krook, A, Zierath, J. R
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.07.2009; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Biological and medical sciences; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzymes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression - physiology; genetics; Glucose; Glucose metabolism; Homeostasis; Human Physiology; Humans; Insulin; Insulin - metabolism; Insulin resistance; Insulin signalling; Internal Medicine; Kinases; lipid metabolism; Lipids; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Muscle, Skeletal; Muscle, Skeletal - physiology; Musculoskeletal system; Phosphorylation; Physiology; protein phosphorylation; Proteins; Review; RNA polymerase; RNA, Small Interfering; Signal Transduction; Signal Transduction - physiology; siRNA; skeletal muscle; Striated muscle. Tendons; Target validation; therapeutics; Vertebrates: osteoarticular system, musculoskeletal system; Glucose metabolism; Therapy; Target validation; siRNA; Insulin signalling; Lipid metabolism; Gene expression; Protein phosphorylation; Skeletal muscle; Endocrinopathy; Human; Pancreatic hormone; Phosphorylation; RNA; Diabetes mellitus; Lipids; Glucose; Striated muscle; Metabolism; Insulin; Protein; Specificity

Insulin action on metabolically active tissues is a complex process involving positive and negative feedback regulation to control whole body glucose homeostasis. At the cellular level, glucose and lipid metabolism, as well as protein synthesis, are controlled through canonical insulin signalling ca...