Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice

• Published in: The Journal of nutritional biochemistry Vol. 32; pp. 73 - 84
• Main Authors: Shawky, Noha M., Pichavaram, Prahalathan, Shehatou, George S.G., Suddek, Ghada M., Gameil, Nariman M., Jun, John Y., Segar, Lakshman
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Anti-Obesity Agents - administration & dosage; Anti-Obesity Agents - pharmacology; Anti-Obesity Agents - therapeutic use; Anticarcinogenic Agents - administration & dosage; Anticarcinogenic Agents - pharmacology; Anticarcinogenic Agents - therapeutic use; Antioxidants - administration & dosage; Antioxidants - pharmacology; Antioxidants - therapeutic use; Aorta; Arterial injury; Cell Proliferation - drug effects; Cells, Cultured; Diet, Western - adverse effects; Diet-induced obesity; Femoral Artery - injuries; Humans; Injections, Subcutaneous; Insulin Resistance; Isothiocyanates - administration & dosage; Isothiocyanates - pharmacology; Isothiocyanates - therapeutic use; Leptin; Leptin - antagonists & inhibitors; Leptin - metabolism; Male; Mice, Inbred C57BL; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - immunology; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Neointima - immunology; Neointima - metabolism; Neointima - pathology; Neointima - prevention & control; Obesity - drug therapy; Obesity - immunology; Obesity - metabolism; Obesity - pathology; Oxidative Stress - drug effects; p70S6K; Sulforaphane; Vascular smooth muscle cells; Weight Gain - drug effects; Diet-induced obesity; p70S6K; Arterial injury; Sulforaphane; Leptin; Vascular smooth muscle cells

Sulforaphane (SFN), a dietary phase-2 enzyme inducer that mitigates cellular oxidative stress through nuclear factor erythroid 2-related factor 2 (Nrf2) activation, is known to exhibit beneficial effects in the vessel wall. For instance, it inhibits vascular smooth muscle cell (VSMC) proliferation,...