Genome-wide association study identifies two loci influencing plasma neurofilament light levels

• Published in: BMC medical genomics Vol. 11; no. 1; pp. 47 - 8
• Main Authors: Li, Jie-Qiong, Yuan, Xiang-Zhen, Li, Hai-Yan, Cao, Xi-Peng, Yu, Jin-Tai, Tan, Lan, Chen, Wei-An
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.05.2018; BioMed Central; BMC
• Subjects: Alzheimer disease; Cytoplasmic filaments; GABRB2; Genetic factors; Genome-wide association studies; Genome-wide association study; LUZP2; Plasma NFL; GABRB2; Plasma NFL; Genetic factors; Genome-wide association study; Alzheimer disease; LUZP2

Plasma neurofilament light (NFL) is a promising biomarker for Alzheimer disease (AD), which increases in the early stage of AD and is associated with the progression of AD. We performed a genome-wide association study (GWAS) of plasma NFL in Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1...