Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression

• Published in: Journal of experimental & clinical cancer research Vol. 42; no. 1; pp. 9 - 18
• Main Authors: Deng, Min, Zhang, Long, Zheng, Wenying, Chen, Jiale, Du, Nan, Li, Meiqi, Chen, Weiqing, Huang, Yonghong, Zeng, Ning, Song, Yuanbin, Chen, Yongming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.01.2023; BioMed Central; BMC
• Subjects: Acetates; Acetylation; Acetyltransferases - metabolism; Cancer; Comparative analysis; Development and progression; Enzymes; Gastric cancer; Genetic translation; Health aspects; Helicobacter pylori; Helicobacter pylori - genetics; Humans; MDM2; Messenger RNA; N-acetyltransferase 10; N-Terminal Acetyltransferases - metabolism; N4-acetylcytidine; p53; Proto-Oncogene Proteins c-mdm2 - genetics; Proto-Oncogene Proteins c-mdm2 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stomach cancer; Stomach Neoplasms - genetics; Tumor proteins; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; MDM2; Helicobacter pylori; N-acetyltransferase 10; Gastric cancer; N4-acetylcytidine; p53

N4-acetylcytidine (ac4C), a widespread modification in human mRNAs that is catalyzed by the N-acetyltransferase 10 (NAT10) enzyme, plays an important role in promoting mRNA stability and translation. However, the biological functions and regulatory mechanisms of NAT10-mediated ac4C were poorly defin...