Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 11; pp. 4221 - 4226
• Main Authors: Wu, Wen-Chao, Sun, Hong-Wei, Chen, Hai-Tian, Liang, Jing, Yu, Xing-Juan, Wu, Chong, Wang, Zilian, Zheng, Limin
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 18.03.2014; National Acad Sciences
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antigens, CD34 - metabolism; Biological Sciences; Blood; Bone marrow; Cancer; Cell Culture Techniques; Cell Differentiation - immunology; Cellular biology; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - immunology; Hepatocellular carcinoma; Humans; Interleukin-6 - immunology; Male; Middle Aged; Myeloid cells; Myeloid Cells - cytology; Myeloid Cells - immunology; Neoplasms - genetics; Neoplasms - immunology; Oncology; Physiology; Progenitor cells; Rodents; Stem cells; Stem Cells - cytology; Stem Cells - immunology; T lymphocytes; Tumors

Cancer is associated with a profound perturbation in myelopoiesis that results in the accumulation of myeloid-derived suppressor cells (MDSCs) to promote disease progression. Recent studies in mice suggest that tumor-derived factors could regulate the differentiation of hematopoietic stem and progen...