Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course - Castro, Kamilah; Ntranos, Achilles; Amatruda, Mario; Petracca, Maria; Kosa, Peter; Chen, Emily Y.; Morstein, Johannes; Trauner, Dirk; Watson, Corey T.; Kiebish, Michael A.; Bielekova, Bibiana; Inglese, Matilde; et al. (EBioMedicine, 2019)
Keywords: Advanced Basic Science; Animals; Biomarkers; Body Mass Index; Brain - pathology; Ceramides - metabolism; Ceramides - pharmacology; Disease Models, Animal; Disease Progression; Disease Susceptibility; DNA Methylation - drug effects; Epigenesis, Genetic; Epigenetics; Epigenomics - methods; Female; Humans; Immunity; Internal Medicine; Leukocyte Count; Lipid Metabolism - drug effects; Lipids; Lipids - blood; Male; Metabolome; Metabolomics - methods; Mice; Monocytes - drug effects; Monocytes - immunology; Monocytes - metabolism; Multiple Sclerosis - diagnostic imaging; Multiple Sclerosis - etiology; Multiple Sclerosis - metabolism; Multiple Sclerosis - pathology; Neurodegeneration; Obesity; Obesity - complications; Obesity - metabolism; Organ Size; Research paper; Transcription, Genetic; Epigenetics; Obesity; Lipids; Neurodegeneration; Immunity