The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver

• Published in: Toxicology (Amsterdam) Vol. 459; p. 152854
• Main Authors: Leitch, Alistair C., Ibrahim, Ibrahim, Abdelghany, Tarek M., Charlton, Alex, Roper, Clair, Vidler, Dan, Palmer, Jeremy M., Wilson, Colin, Jones, David E., Blain, Peter G., Wright, Matthew C.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2021; Elsevier
• Subjects: Acetaldehyde dehydrogenase; Alcohol dehydrogenase; alcohols; Bile; C8mim; carboxylation; carboxylic acids; cytochrome P-450; Cytochromes P450; disulfiram; Emergency; excretion; hepatocytes; human population; humans; hydroxylation; Ionic liquids; ketoconazole; liver; liver diseases; metabolism; metabolites; oxidation; patients; toxicology; PBS; DCD; ALP; M8OI; Acetaldehyde dehydrogenase; DBD; ALT; FMO; Alcohol dehydrogenase; PFOA; HO8IM; PDC; PBC; AMA; C8mim; Ionic liquids; CYP; MI; COOH7IM; PFOS; Cytochromes P450; Bile; donation after brain death; alanine aminotransferase; flavin-containing monooxygenases; perfluorooctanesulfonic acid; 1-(7-carboxyheptyl)-3-methyl-1H-imidazol-3-ium; pyruvate dehydrogenase complex; alkaline phosphatase; anti-mitochondrial antibody; 1-octyl 3-methylimidazolium chloride salt; 1-(8-hydroxyoctyl)-3-methyl-imidazolium; cytochrome P450; perfluorooctanoic acid; methylimidazolium cation; 1-octyl 3-methylimidazolium cation; phosphate buffered saline; donation after circulatory death; primary biliary cholangitis

•M8OI was recently found to be contaminating the environment.•M8OI was detected in the sera from 5/20 PBC patients and 1/10 controls.•M8OI is taken up by human liver hepatocytes.•M8OI is sequentially metabolised by CYPs followed by oxidation by dehydrogenases.•The final carboxylic acid metabolite CO...