Computational adaptive optics for broadband optical interferometric tomography of biological tissue

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 19; pp. 7175 - 7180
• Main Authors: Adie, Steven G., Graf, Benedikt W., Ahmad, Adeel, Carney, P. Scott, Boppart, Stephen A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 08.05.2012; National Acad Sciences
• Subjects: Adaptability; Adaptive optics; Algorithms; animal tissues; Animals; Biological samples; Biological Sciences; Broadband transmission; data collection; Fiber optic interferometers; Fourier transformations; image analysis; Image Processing, Computer-Assisted - instrumentation; Image Processing, Computer-Assisted - methods; Imaging; Imaging, Three-Dimensional - instrumentation; Imaging, Three-Dimensional - methods; Interferometry; Light microscopy; Lung - anatomy & histology; Lungs; Microscopy; Microscopy, Interference - instrumentation; Microscopy, Interference - methods; Optical coherence tomography; Optical focus; Optics; Phantoms, Imaging; Physical Sciences; Rats; Reproducibility of Results; Rodents; Supernova remnants; Tissues; Tomography; Tomography, Optical Coherence - instrumentation; Tomography, Optical Coherence - methods

Aberrations in optical microscopy reduce image resolution and contrast, and can limit imaging depth when focusing into biological samples. Static correction of aberrations may be achieved through appropriate lens design, but this approach does not offer the flexibility of simultaneously correcting a...