Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women

• Published in: Gynecologic oncology Vol. 153; no. 2; pp. 343 - 355
• Main Authors: Lawrenson, Kate, Song, Fengju, Hazelett, Dennis J., Kar, Siddhartha P., Tyrer, Jonathan, Phelan, Catherine M., Corona, Rosario I., Rodríguez-Malavé, Norma I., Seo, Ji-Hei, Adler, Emily, Coetzee, Simon G., Segato, Felipe, Fonseca, Marcos A.S., Amos, Christopher I., Carney, Michael E., Chenevix-Trench, Georgia, Choi, Jiyeob, Doherty, Jennifer A., Jia, Weihua, Jin, Gang J., Kim, Byoung-Gie, Le, Nhu D., Lee, Juyeon, Li, Lian, Lim, Boon K., Adenan, Noor A., Mizuno, Mika, Park, Boyoung, Pearce, Celeste L., Shan, Kang, Shi, Yongyong, Shu, Xiao-Ou, Sieh, Weiva, Thompson, Pamela J., Wilkens, Lynne R., Wei, Qingyi, Woo, Yin L., Yan, Li, Karlan, Beth Y., Freedman, Matthew L., Noushmehr, Houtan, Goode, Ellen L., Berchuck, Andrew, Sellers, Thomas A., Teo, Soo-Hwang, Zheng, Wei, Matsuo, Keitaro, Park, Sue, Chen, Kexin, Pharoah, Paul D.P., Gayther, Simon A., Goodman, Marc T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019
• Subjects: Asian ancestry; Asian People - genetics; Base Sequence; Carcinoma, Ovarian Epithelial - genetics; Case-Control Studies; Enhancer; Epithelial ovarian cancer; eQTL; Female; Gene regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Hematology, Oncology, and Palliative Medicine; Humans; Obstetrics and Gynecology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Asian ancestry; eQTL; Genome-wide association study; Enhancer; Epithelial ovarian cancer; Gene regulation

Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women. Genotyping was performed as part of the OncoArray project. Samples with >60%...