The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

• Published in: Stem cell reports Vol. 17; no. 5; pp. 1089 - 1104
• Main Authors: Muhl, Lars, He, Liqun, Sun, Ying, Andaloussi Mäe, Maarja, Pietilä, Riikka, Liu, Jianping, Genové, Guillem, Zhang, Lei, Xie, Yuan, Leptidis, Stefanos, Mocci, Giuseppe, Stritt, Simon, Osman, Ahmed, Anisimov, Andrey, Hemanthakumar, Karthik Amudhala, Räsänen, Markus, Hansson, Emil M., Björkegren, Johan, Vanlandewijck, Michael, Blomgren, Klas, Mäkinen, Taija, Peng, Xiao-Rong, Hu, Yizhou, Ernfors, Patrik, Arnold, Thomas D., Alitalo, Kari, Lendahl, Urban, Betsholtz, Christer
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.05.2022; Elsevier
• Subjects: Angiotensin converting enzyme 2 (ACE2); Angiotensin-Converting Enzyme 2 - metabolism; Animals; Cardiovascular Diseases - virology; COVID-19; COVID-19 - complications; Endothelial Cells; Mice; pericytes; Pericytes - metabolism; SARS-CoV-2; single-cell RNA-sequencing; Vasculature; COVID-19; single-cell RNA-sequencing; SARS-CoV-2; Endothelial Cells; Angiotensin converting enzyme 2 (ACE2); pericytes; Vasculature

Humanized mouse models and mouse-adapted SARS-CoV-2 virus are increasingly used to study COVID-19 pathogenesis, so it is important to learn where the SARS-CoV-2 receptor ACE2 is expressed. Here we mapped ACE2 expression during mouse postnatal development and in adulthood. Pericytes in the CNS, heart...