Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway

• Published in: Journal of experimental & clinical cancer research Vol. 41; no. 1; pp. 76 - 16
• Main Authors: Li, Yujia, Chen, Hui, Yang, Qi, Wan, Lixin, Zhao, Jing, Wu, Yuanyuan, Wang, Jiaxin, Yang, Yating, Niu, Menglan, Liu, Hongliang, Liu, Junqi, Yang, Hushan, Wan, Shaogui, Wang, Yanming, Bao, Dengke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.02.2022; BioMed Central; BMC
• Subjects: Animals; Autophagy; Cell Line, Tumor; Cell Proliferation; cGAS-STING signaling pathway; Development and progression; Disease Progression; DNA, Mitochondrial - pharmacology; DNA, Mitochondrial - therapeutic use; Drp1; Dynamins - metabolism; Esophageal cancer; Esophageal Squamous Cell Carcinoma; Female; Humans; Immune response; Medical research; Medicine, Experimental; Mice; Mice, Knockout; Mice, Nude; Mitochondrial DNA; Mitochondrial DNA stress; Nucleotidyltransferases - metabolism; Photographic industry; Physiological aspects; Squamous cell carcinoma; Japan; Mitochondrial DNA stress; cGAS-STING signaling pathway; Autophagy; Drp1; Esophageal Squamous Cell Carcinoma

Mitochondrial dynamics homeostasis is important for cell metabolism, growth, proliferation, and immune responses. The critical GTPase for mitochondrial fission, Drp1 is frequently upregulated in many cancers and is closely implicated in tumorigenesis. However, the mechanism underling Drp1 to influen...