Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments

• Published in: Chinese medicine Vol. 18; no. 1; pp. 7 - 14
• Main Authors: Wang, Haojia, Wu, Zhishan, Fan, Xiaotian, Wu, Chao, Lu, Shan, Geng, Libo, Stalin, Antony, Zhu, Yingli, Zhang, Fanqin, Huang, Jiaqi, Liu, Pengyun, Li, Huiying, You, Leiming, Wu, Jiarui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.01.2023; BioMed Central; BMC
• Subjects: Aidi injection; Analysis; Cancer; Care and treatment; Liquid chromatography; Mass spectrometry; Molecular docking; Network pharmacology; Pancreatic cancer; Pharmacodynamic evaluation; Pharmacology; Tumor proteins; China; Network pharmacology; Aidi injection; Pharmacodynamic evaluation; Pancreatic cancer; Molecular docking

Pancreatic cancer is one of the most lethal cancers worldwide. Aidi injection (ADI) is a representative antitumor medication based on Chinese herbal injection, but its antitumor mechanisms are still poorly understood. In this work, the subcutaneous xenograft model of human pancreatic cancer cell lin...