Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors

• Published in: EBioMedicine Vol. 41; pp. 443 - 454
• Main Authors: Van Hecke, Clarissa, Trypsteen, Wim, Malatinkova, Eva, De Spiegelaere, Ward, Vervisch, Karen, Rutsaert, Sofie, Kinloch-de Loes, Sabine, Sips, Magdalena, Vandekerckhove, Linos
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019; Elsevier
• Subjects: Adult; Advanced Basic Science; Antiretroviral Therapy, Highly Active; Biomarkers; CD4 Lymphocyte Count; Cohorts; Disease Progression; Early treatment; Female; Gene Expression Profiling; Gene Expression Regulation; HIV Infections - drug therapy; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - virology; HIV Seropositivity; HIV-1; HIV-1 infection; Host-Pathogen Interactions - genetics; Humans; Internal Medicine; LTNP; Male; Middle Aged; Phenotype; Research paper; Restriction factors; Time-to-Treatment; Viral Load; Virus Replication; LTNP; HIV-1 infection; Early treatment; Restriction factors; Cohorts

A wide range of host restriction factors (RF) become upregulated upon HIV-1 infection to suppress viral infectivity and may aid viremic control in vivo. This cross-sectional study evaluated HIV-1 RFs and dependency factors in HIV infected individuals with progressive or non-progressive infection, as...