Characterization of a polyketide synthase in Aspergillus niger whose product is a precursor for both dihydroxynaphthalene (DHN) melanin and naphtho-γ-pyrone

• Published in: Fungal genetics and biology Vol. 48; no. 4; pp. 430 - 437
• Main Authors: Chiang, Yi-Ming, Meyer, Kristen M., Praseuth, Michael, Baker, Scott E., Bruno, Kenneth S., Wang, Clay C.C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2011
• Subjects: ASPERGILLUS; Aspergillus fumigatus; Aspergillus niger; Aspergillus niger - enzymology; Aspergillus niger - genetics; BASIC BIOLOGICAL SCIENCES; biochemical pathways; BIOSYNTHESIS; ENZYMES; enzymology; filamentous fungi, secondary metabolite, naptha gamma pyrone; fungi; Gene Deletion; GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; GENES; genetics; Genomics; MELANIN; Melanins; Melanins - metabolism; metabolism; METABOLITES; Naphtho-γ-pyrone; Naphthols; Naphthols - metabolism; Natural products; NIGER; Polyketide Synthases; Polyketide Synthases - genetics; Polyketide Synthases - metabolism; Polyketides; PRECURSOR; PRODUCTION; Pyrones; Pyrones - metabolism; Secondary metabolism; secondary metabolites; spores; STRAINS; Naphtho-γ-pyrone; Polyketides; Aspergillus niger; Natural products; Secondary metabolism; Genomics

The genome sequencing of the fungus Aspergillus niger uncovered a large cache of genes encoding enzymes thought to be involved in the production of secondary metabolites yet to be identified. Identification and structural characterization of many of these predicted secondary metabolites are hampered...