TNFR1 signaling kinetics: Spatiotemporal control of three phases of IKK activation by posttranslational modification - Workman, Lauren M.; Habelhah, Hasem (Cellular signalling, 2013)
Keywords: Activation; Animals; CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism; cIAP1; Cytokines; Humans; I-kappa B Kinase - metabolism; inflammation; Inflammatory response; JNK Mitogen-Activated Protein Kinases - metabolism; Kinases; NF-kappa B - metabolism; NF-κB; Nuclear Pore Complex Proteins - metabolism; Pathways; Phases; Protein Processing, Post-Translational; protein-serine-threonine kinases; Reactive Oxygen Species - metabolism; Receptors, Tumor Necrosis Factor, Type I - chemistry; Receptors, Tumor Necrosis Factor, Type I - metabolism; RIP1; RNA-Binding Proteins - metabolism; serine; Signal Transduction; Strategy; Three phase; threonine; TNF Receptor-Associated Factor 2 - genetics; TNF Receptor-Associated Factor 2 - metabolism; TNFα; TRAF2; transcription factor NF-kappa B; tumor necrosis factor-alpha; ubiquitination; TNFα; cFLIP; TRAF; JNK; TRADD; cIAP1; TNF; IκB; NF-κB; S1P; TBK1; TAK1; DICS; UBD; SM; FADD; MEFs; TNFR; KO; MEKK1; IL-1; ASK1; IKK; DKO; TRAF2; LUBAC; IL-6; RA; NIK; ROS; TAB1; RIP1