Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

• Published in: Microbiome Vol. 6; no. 1; pp. 35 - 16
• Main Authors: Mullaney, Jane A., Stephens, Juliette E., Costello, Mary-Ellen, Fong, Cai, Geeling, Brooke E., Gavin, Patrick G., Wright, Casey M., Spector, Timothy D., Brown, Matthew A., Hamilton-Williams, Emma E.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.02.2018; BioMed Central; BMC
• Subjects: Analysis; Animals; Autoimmunity; Cation Transport Proteins - genetics; Clostridiales - isolation & purification; CTLA-4 Antigen - genetics; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Disease susceptibility; Dysbiosis - microbiology; Dysbiosis - pathology; Female; Gastrointestinal Microbiome; Gastrointestinal Tract - immunology; Gastrointestinal Tract - microbiology; Genetic aspects; Genetic Predisposition to Disease - genetics; Genetic susceptibility; Gut microbiota; Humans; Interleukin-2 - genetics; Interleukin-2 - metabolism; Interleukin-2 pathway; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Microbiota (Symbiotic organisms); Physiological aspects; Risk factors; Ruminococcus - isolation & purification; Type 1 diabetes; New Zealand; Australia; Autoimmunity; Gut microbiota; Interleukin-2 pathway; Genetic susceptibility; Type 1 diabetes

Dysbiosis of the gut microbiota has been implicated in the pathogenesis of many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether changes in the gut microbiota observed in T1D are due to environmental drivers, genetic risk factors, or both. Here, we have performed an analy...