Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

• Published in: The FASEB journal Vol. 31; no. 4; p. 1273
• Main Author: Serhan, Charles N
• Format: Journal Article
• Language: English
• Published: United States 01.04.2017
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Clinical Trials as Topic; Fatty Acids, Omega-3 - metabolism; Humans; Infections - drug therapy; Infections - metabolism; Inflammation Mediators - metabolism; Inflammation Mediators - pharmacology; Inflammation Mediators - therapeutic use; maresins; leukocytes; lipoxins; omega-3 PUFA; resolvins; protectins

Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept...