Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept...
Saved in:
| Published in | The FASEB journal Vol. 31; no. 4; p. 1273 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.04.2017
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept has not changed. Because the acute inflammatory response is host protective to contain foreign invaders, much of today's pharmacopeia can cause serious unwanted side effects, such as immune suppression. Uncontrolled inflammation is now considered pathophysiologic and is associated with many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity, and asthma, as well as classic inflammatory diseases (
, arthritis and periodontal diseases). The inflammatory response, when self-limited, produces a superfamily of chemical mediators that stimulate resolution of the response. Specialized proresolving mediators (SPMs), identified in recent years, are endogenous mediators that include the n-3-derived families resolvins, protectins, and maresins, as well as arachidonic acid-derived (n-6) lipoxins, which promote resolution of inflammation, clearance of microbes, reduction of pain, and promotion of tissue regeneration
novel mechanisms. Aspirin and statins have a positive impact on these resolution pathways, producing epimeric forms of specific SPMs, whereas other drugs can disrupt timely resolution. In this article, evidence from recent human and preclinical animal studies is reviewed, indicating that SPMs are physiologic mediators and pharmacologic agonists that stimulate resolution of inflammation and infection. The findings suggest that it is time to challenge current treatment practices-namely, using inhibitors and antagonists alone-and to develop immunoresolvents as agonists to test resolution pharmacology and their role in catabasis for their therapeutic potential.-Serhan, C. N. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms. |
|---|---|
| AbstractList | Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept has not changed. Because the acute inflammatory response is host protective to contain foreign invaders, much of today's pharmacopeia can cause serious unwanted side effects, such as immune suppression. Uncontrolled inflammation is now considered pathophysiologic and is associated with many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity, and asthma, as well as classic inflammatory diseases (
, arthritis and periodontal diseases). The inflammatory response, when self-limited, produces a superfamily of chemical mediators that stimulate resolution of the response. Specialized proresolving mediators (SPMs), identified in recent years, are endogenous mediators that include the n-3-derived families resolvins, protectins, and maresins, as well as arachidonic acid-derived (n-6) lipoxins, which promote resolution of inflammation, clearance of microbes, reduction of pain, and promotion of tissue regeneration
novel mechanisms. Aspirin and statins have a positive impact on these resolution pathways, producing epimeric forms of specific SPMs, whereas other drugs can disrupt timely resolution. In this article, evidence from recent human and preclinical animal studies is reviewed, indicating that SPMs are physiologic mediators and pharmacologic agonists that stimulate resolution of inflammation and infection. The findings suggest that it is time to challenge current treatment practices-namely, using inhibitors and antagonists alone-and to develop immunoresolvents as agonists to test resolution pharmacology and their role in catabasis for their therapeutic potential.-Serhan, C. N. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms. |
| Author | Serhan, Charles N |
| Author_xml | – sequence: 1 givenname: Charles N surname: Serhan fullname: Serhan, Charles N email: cserhan@bwh.harvard.edu organization: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA cserhan@bwh.harvard.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28087575$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j1tLAzEQhYMo9qKPvkr-wNZktsmmvknxBgWh1OeSTmZtSpMtmyzSf--26tPhzGE-zhmxy9hEYuxOiokUM_1Q7yYgpBYSAJYXbChVKQpttBiwUUo7IYTs42s2ACNMpSo1ZHnVks0-fnEf670NoTdN5Da604Hw7HzkeUscZMocKeauPT7ySN9862NOvG6bwB1h406cllKz785_gZy3uWnTmRcItzb6FNINu6rtPtHtn47Z58vzav5WLD5e3-dPiwKV1ssCnOkLaycN2tIRIRiLUFdiY0u1mYETCggrMmaKAsmWgDhV05nVRiFKCWN2_8s9dJu-y_rQ-mDb4_p_PvwA_g9epw |
| CitedBy_id | crossref_primary_10_1039_C8OB01232F crossref_primary_10_3390_molecules24183228 crossref_primary_10_1016_j_ejmech_2019_02_034 crossref_primary_10_1016_j_imlet_2020_11_009 crossref_primary_10_1371_journal_pone_0291399 crossref_primary_10_3390_ijms242115996 crossref_primary_10_1007_s12414_018_0318_2 crossref_primary_10_1016_j_phymed_2019_152881 crossref_primary_10_1096_fj_201701173RR crossref_primary_10_1186_s12884_022_05282_x crossref_primary_10_3390_molecules25122953 crossref_primary_10_3389_fimmu_2020_01726 crossref_primary_10_1213_ANE_0000000000004792 crossref_primary_10_1039_D2RA05558A crossref_primary_10_1080_09540105_2023_2249261 crossref_primary_10_1016_j_bbadis_2021_166199 crossref_primary_10_1051_wujns_2024291085 crossref_primary_10_2478_sjecr_2020_0013 crossref_primary_10_3390_ijms23094808 crossref_primary_10_1016_j_arr_2019_100980 crossref_primary_10_3233_JAD_190682 crossref_primary_10_1016_j_scib_2024_07_049 crossref_primary_10_3389_fimmu_2021_727861 crossref_primary_10_1021_acs_jmedchem_7b01136 crossref_primary_10_1111_prd_12227 crossref_primary_10_1172_jci_insight_137713 crossref_primary_10_1007_s12026_024_09575_5 crossref_primary_10_1159_000500422 crossref_primary_10_2174_1389557521666201217144954 crossref_primary_10_1016_j_jfscie_2022_100016 crossref_primary_10_1016_j_ejmech_2019_03_052 crossref_primary_10_1172_JCI97943 crossref_primary_10_1039_D1OB01932E crossref_primary_10_1016_j_identj_2024_11_016 crossref_primary_10_1016_j_jep_2024_118478 crossref_primary_10_1016_j_ejphar_2023_176163 crossref_primary_10_1002_sctm_19_0078 crossref_primary_10_1038_s41401_022_00944_0 crossref_primary_10_1146_annurev_food_032818_121316 crossref_primary_10_1055_a_2440_5166 crossref_primary_10_4103_0366_6999_229890 crossref_primary_10_23736_S2724_5985_21_02934_X crossref_primary_10_1172_jci_insight_144351 crossref_primary_10_3389_fneur_2018_00617 crossref_primary_10_1080_14756366_2021_1956912 crossref_primary_10_3389_fimmu_2017_01400 crossref_primary_10_1016_j_fitote_2017_09_015 crossref_primary_10_1016_j_biopsych_2019_07_015 crossref_primary_10_1111_cei_13481 crossref_primary_10_1007_s10068_022_01052_9 crossref_primary_10_1016_j_prostaglandins_2023_106733 crossref_primary_10_1016_j_bbih_2022_100554 crossref_primary_10_1016_j_jff_2018_12_033 crossref_primary_10_1016_j_mam_2017_04_005 crossref_primary_10_3390_ijms22084207 crossref_primary_10_1093_cvr_cvz058 crossref_primary_10_3390_ijms22094370 crossref_primary_10_1016_j_crneur_2023_100093 crossref_primary_10_1111_jre_12938 crossref_primary_10_1016_j_phytol_2019_02_003 crossref_primary_10_1021_acsmedchemlett_2c00079 crossref_primary_10_1016_j_tetlet_2019_151510 crossref_primary_10_1016_j_prostaglandins_2017_05_005 crossref_primary_10_1016_j_prostaglandins_2022_106619 crossref_primary_10_1155_2022_8527305 crossref_primary_10_1016_j_fitote_2018_04_003 crossref_primary_10_1016_j_lfs_2018_12_048 crossref_primary_10_1016_j_lfs_2020_118591 crossref_primary_10_1111_all_14217 crossref_primary_10_1186_s12903_023_03359_3 crossref_primary_10_3389_fphar_2020_00203 crossref_primary_10_7759_cureus_21742 crossref_primary_10_1038_s41575_018_0009_6 crossref_primary_10_1007_s11538_020_00709_y crossref_primary_10_1016_j_bbalip_2018_11_012 crossref_primary_10_1038_s41598_017_05433_7 crossref_primary_10_1096_fj_202101219RR crossref_primary_10_3390_physiologia3020022 crossref_primary_10_1007_s00281_019_00771_2 crossref_primary_10_1007_s00430_023_00777_6 crossref_primary_10_1007_s10787_023_01366_y crossref_primary_10_1053_j_gastro_2018_06_031 crossref_primary_10_4049_jimmunol_1700315 crossref_primary_10_3390_ijms22094393 crossref_primary_10_1016_j_bbalip_2019_06_010 crossref_primary_10_1111_joim_12871 crossref_primary_10_3389_fimmu_2021_660760 crossref_primary_10_3390_cells12010122 crossref_primary_10_3390_ijms21186637 crossref_primary_10_1016_j_compbiolchem_2024_108236 crossref_primary_10_1016_j_prostaglandins_2017_06_003 crossref_primary_10_3390_molecules27051677 crossref_primary_10_1042_CS20190768 crossref_primary_10_1007_s10753_018_0867_7 crossref_primary_10_3390_ijms23158745 crossref_primary_10_1038_s41580_019_0108_4 crossref_primary_10_1074_jbc_R117_783076 crossref_primary_10_1152_ajpgi_00194_2021 crossref_primary_10_1016_j_anndiagpath_2021_151865 crossref_primary_10_1111_febs_16266 crossref_primary_10_1096_fj_201800173R crossref_primary_10_3389_fphar_2019_01022 crossref_primary_10_1016_j_pharmthera_2023_108453 crossref_primary_10_1177_00220345221090879 crossref_primary_10_1038_s41582_023_00777_3 crossref_primary_10_3390_ijms241612623 crossref_primary_10_1016_j_copbio_2018_01_008 crossref_primary_10_1021_acs_jmedchem_1c00403 crossref_primary_10_1016_j_mehy_2020_110340 crossref_primary_10_1016_j_prostaglandins_2024_106944 crossref_primary_10_3390_molecules24224147 crossref_primary_10_32947_ajps_v25i1_1148 crossref_primary_10_3389_fimmu_2021_763334 crossref_primary_10_3390_molecules27248732 crossref_primary_10_3390_bioengineering10040488 crossref_primary_10_3390_ph14121209 crossref_primary_10_1016_j_prostaglandins_2023_106787 crossref_primary_10_25122_jml_2024_008 crossref_primary_10_3390_ijms21249577 crossref_primary_10_1016_j_cbi_2018_05_018 crossref_primary_10_1038_s41419_019_2086_z crossref_primary_10_1016_j_ejphar_2021_174693 crossref_primary_10_1016_j_prostaglandins_2024_106814 crossref_primary_10_1096_fj_201900542R crossref_primary_10_5493_wjem_v12_i1_1 crossref_primary_10_3389_fphys_2021_729134 crossref_primary_10_1016_j_matt_2024_09_016 crossref_primary_10_1016_j_prostaglandins_2023_106798 crossref_primary_10_1097_j_pain_0000000000003088 crossref_primary_10_3390_vaccines6020021 crossref_primary_10_3389_fimmu_2021_658715 crossref_primary_10_3389_fnmol_2021_612073 crossref_primary_10_1016_j_tetlet_2020_151857 crossref_primary_10_2460_ajvr_21_08_0126 crossref_primary_10_3390_ijms21165783 crossref_primary_10_1016_j_burns_2024_107345 crossref_primary_10_1111_1471_0528_17613 crossref_primary_10_3389_fmed_2024_1410668 crossref_primary_10_7759_cureus_21095 crossref_primary_10_1016_j_nut_2019_02_016 crossref_primary_10_1016_j_mam_2020_100894 crossref_primary_10_1177_1756286418791107 crossref_primary_10_1016_j_phrs_2022_106337 crossref_primary_10_1002_edm2_105 crossref_primary_10_1016_j_tips_2018_01_003 crossref_primary_10_3390_nano14201642 crossref_primary_10_1002_lipd_12359 crossref_primary_10_1213_ANE_0000000000004053 crossref_primary_10_1007_s10571_023_01363_3 crossref_primary_10_3389_fimmu_2019_01699 crossref_primary_10_1016_j_neuropharm_2022_109189 crossref_primary_10_1016_j_plefa_2024_102642 crossref_primary_10_1016_j_bioorg_2020_103653 crossref_primary_10_1152_physrev_00010_2018 crossref_primary_10_1016_j_ejps_2020_105300 crossref_primary_10_1096_fj_201900423R crossref_primary_10_3389_fimmu_2024_1424768 crossref_primary_10_3389_fphar_2019_00420 crossref_primary_10_1172_jci_insight_125191 crossref_primary_10_3390_biomedicines12102221 crossref_primary_10_1111_febs_15803 crossref_primary_10_1155_2018_5086516 crossref_primary_10_1016_j_biochi_2021_05_017 crossref_primary_10_1016_j_neuroscience_2023_08_004 crossref_primary_10_2478_sjecr_2020_0043 crossref_primary_10_1093_brain_awy247 crossref_primary_10_3390_jcm12196271 crossref_primary_10_1016_j_intimp_2021_108348 crossref_primary_10_3389_fimmu_2021_659943 crossref_primary_10_1016_j_metabol_2019_04_011 crossref_primary_10_1038_s41386_019_0439_z crossref_primary_10_1096_fj_201700268 crossref_primary_10_1002_adma_201705328 crossref_primary_10_1016_S1441_2772_23_00390_3 crossref_primary_10_1021_acsptsci_9b00097 crossref_primary_10_1155_2022_9966750 crossref_primary_10_1007_s11894_018_0647_4 crossref_primary_10_3390_ijms23179918 crossref_primary_10_1016_j_ajem_2020_04_096 crossref_primary_10_1096_fj_201700319R crossref_primary_10_3389_fimmu_2021_633324 crossref_primary_10_1080_10408398_2022_2146044 crossref_primary_10_3389_fphar_2018_01536 crossref_primary_10_17116_anaesthesiology202206199 crossref_primary_10_1111_nyas_14907 crossref_primary_10_1016_j_phrs_2019_104549 crossref_primary_10_1016_j_tetlet_2019_151473 crossref_primary_10_3389_fphar_2018_01535 crossref_primary_10_1016_j_tetlet_2018_02_029 crossref_primary_10_1371_journal_pone_0287392 crossref_primary_10_4155_fmc_2017_0109 crossref_primary_10_3389_fpsyt_2018_00752 crossref_primary_10_3389_fcimb_2022_1002856 crossref_primary_10_1016_j_lfs_2022_120847 crossref_primary_10_1111_cts_12930 crossref_primary_10_1016_j_prostaglandins_2023_106762 crossref_primary_10_1080_14728222_2019_1599360 crossref_primary_10_3389_fncel_2019_00466 crossref_primary_10_1080_14728222_2017_1364363 crossref_primary_10_1096_fj_201902172R crossref_primary_10_1016_j_job_2021_06_002 crossref_primary_10_1096_fj_201902196R crossref_primary_10_1371_journal_pone_0182381 crossref_primary_10_3390_cells10051044 crossref_primary_10_3390_biom11040577 crossref_primary_10_1111_prd_12317 crossref_primary_10_3390_cancers14225703 crossref_primary_10_1021_acsptsci_9b00075 crossref_primary_10_1080_1028415X_2017_1347373 crossref_primary_10_3390_molecules22101720 crossref_primary_10_1002_bab_2739 crossref_primary_10_1016_j_joca_2025_03_005 crossref_primary_10_1016_j_jep_2017_05_029 crossref_primary_10_1080_14786419_2024_2413039 crossref_primary_10_3389_fphar_2018_01582 crossref_primary_10_1016_j_neuron_2018_11_009 crossref_primary_10_1016_j_biopha_2020_111033 crossref_primary_10_1016_j_bcp_2022_115330 crossref_primary_10_1074_jbc_RA119_009972 crossref_primary_10_1016_j_isci_2020_101135 crossref_primary_10_4049_jimmunol_1700933 crossref_primary_10_1096_fj_202002395RR crossref_primary_10_1007_s11914_023_00817_3 crossref_primary_10_3389_fcvm_2022_809935 crossref_primary_10_1016_j_neuroscience_2019_09_008 crossref_primary_10_1016_j_jaut_2020_102528 crossref_primary_10_1186_s12974_022_02386_1 crossref_primary_10_1016_j_jlr_2021_100088 crossref_primary_10_1002_ardp_202100367 crossref_primary_10_1016_j_jand_2020_01_007 crossref_primary_10_1007_s00228_017_2242_2 crossref_primary_10_3390_antiox10020186 crossref_primary_10_1016_j_pharmthera_2021_107879 crossref_primary_10_3389_fphys_2024_1248612 crossref_primary_10_1097_ALN_0000000000002194 crossref_primary_10_22312_sdusbed_1347232 crossref_primary_10_3390_jcm10245799 crossref_primary_10_1096_fj_202400320R crossref_primary_10_53811_ijtcmr_1330957 crossref_primary_10_3389_fnut_2019_00036 crossref_primary_10_3389_fphys_2021_659551 crossref_primary_10_1016_j_phrs_2020_105280 crossref_primary_10_1111_odi_12979 crossref_primary_10_1194_jlr_TR120001137 crossref_primary_10_1093_humrep_deac248 crossref_primary_10_1016_j_neulet_2019_134348 crossref_primary_10_1016_j_bbalip_2023_159395 crossref_primary_10_1093_ajcn_nqab263 crossref_primary_10_1007_s11306_024_02100_7 crossref_primary_10_1080_17512433_2022_2071697 crossref_primary_10_1016_j_phrs_2024_107113 crossref_primary_10_1111_jcmm_16319 crossref_primary_10_1055_s_0043_1777119 crossref_primary_10_1016_j_chembiol_2018_10_023 crossref_primary_10_1002_chem_201806029 crossref_primary_10_1126_scisignal_aar3721 crossref_primary_10_3389_fimmu_2023_1143456 crossref_primary_10_1161_CIRCRESAHA_117_312472 crossref_primary_10_3390_cells9030627 crossref_primary_10_1186_s12916_017_0922_5 crossref_primary_10_1016_j_semcdb_2019_01_011 crossref_primary_10_1039_D4RA04762A crossref_primary_10_1186_s12967_020_02569_5 crossref_primary_10_1016_j_plefa_2020_102156 crossref_primary_10_3389_fimmu_2021_704163 crossref_primary_10_3390_molecules28135032 crossref_primary_10_1039_D0OB02136A crossref_primary_10_1016_j_metabol_2025_156148 crossref_primary_10_1007_s12035_018_0889_z crossref_primary_10_1002_smll_202200895 crossref_primary_10_3390_biom11070937 crossref_primary_10_3390_ph16101415 crossref_primary_10_1007_s13139_020_00645_8 crossref_primary_10_1096_fj_202100078R crossref_primary_10_3389_fimmu_2017_01050 crossref_primary_10_1155_2018_2380319 crossref_primary_10_3233_JAD_179917 crossref_primary_10_3389_fcvm_2022_923413 crossref_primary_10_3390_ijms22010384 crossref_primary_10_1038_s41598_020_66298_x crossref_primary_10_1016_j_clnesp_2018_04_005 crossref_primary_10_1371_journal_pone_0283163 crossref_primary_10_1016_j_jtcme_2021_06_001 crossref_primary_10_1093_cvr_cvaa186 crossref_primary_10_1038_s41467_024_48821_0 crossref_primary_10_1007_s10741_019_09817_x crossref_primary_10_1186_s12903_023_03243_0 crossref_primary_10_3389_fphar_2020_01096 crossref_primary_10_3390_ijms24076064 crossref_primary_10_1002_ccr3_2197 crossref_primary_10_1016_j_joen_2021_01_008 crossref_primary_10_1089_jwh_2017_6432 crossref_primary_10_1097_ALN_0000000000002038 crossref_primary_10_3390_ijms19061812 crossref_primary_10_3390_pharmaceutics13010064 crossref_primary_10_1002_cre2_260 crossref_primary_10_1016_j_plefa_2020_102175 crossref_primary_10_1007_s00281_019_00756_1 crossref_primary_10_35366_105531 crossref_primary_10_1016_j_cell_2021_04_015 crossref_primary_10_1007_s40291_019_00430_0 crossref_primary_10_1016_j_plefa_2018_06_008 crossref_primary_10_1515_revneuro_2017_0074 crossref_primary_10_3390_ijms19010113 crossref_primary_10_1111_bph_14041 crossref_primary_10_1136_thoraxjnl_2018_212616 crossref_primary_10_1186_s12903_021_01619_8 crossref_primary_10_1016_j_biomaterials_2021_121013 crossref_primary_10_3390_nu16183215 crossref_primary_10_1097_BOR_0000000000000463 crossref_primary_10_1016_j_mam_2017_08_002 crossref_primary_10_1016_j_pharmthera_2024_108753 crossref_primary_10_1007_s00011_020_01426_x crossref_primary_10_3390_ijms18122689 crossref_primary_10_1007_s12028_023_01770_w crossref_primary_10_1186_s12903_024_05363_7 crossref_primary_10_3389_fimmu_2021_623941 crossref_primary_10_1007_s12016_020_08796_4 crossref_primary_10_3748_wjg_v27_i25_3815 crossref_primary_10_1007_s12035_019_01757_9 crossref_primary_10_1016_j_plipres_2023_101222 crossref_primary_10_3389_fimmu_2024_1458684 crossref_primary_10_1038_s41392_023_01510_8 crossref_primary_10_1007_s11883_017_0696_4 crossref_primary_10_1016_j_pharmthera_2023_108467 crossref_primary_10_3390_metabo12020192 crossref_primary_10_1016_j_phrs_2020_105340 crossref_primary_10_1016_j_pharmthera_2019_02_001 crossref_primary_10_1002_mnfr_201800990 crossref_primary_10_1016_j_archoralbio_2020_104923 crossref_primary_10_1016_j_mam_2017_03_007 crossref_primary_10_1007_s10103_018_2688_1 crossref_primary_10_1016_j_mam_2017_03_005 crossref_primary_10_3389_fphar_2022_838782 crossref_primary_10_1016_j_mam_2017_03_001 crossref_primary_10_1093_sleep_zsad254 crossref_primary_10_1186_s12931_021_01792_y crossref_primary_10_1002_ddr_22181 crossref_primary_10_1124_pr_117_014092 crossref_primary_10_3389_fimmu_2022_1094278 crossref_primary_10_3389_fimmu_2023_1124774 crossref_primary_10_1016_j_isci_2024_110362 crossref_primary_10_1016_j_ccm_2018_08_008 crossref_primary_10_1016_j_neuropharm_2019_107742 crossref_primary_10_1016_j_jshs_2019_12_003 crossref_primary_10_1080_14728222_2023_2259099 crossref_primary_10_1042_CS20211122 crossref_primary_10_1681_ASN_2017101112 crossref_primary_10_3390_ijms19020468 crossref_primary_10_3390_ijms20235849 crossref_primary_10_1002_ppul_24129 crossref_primary_10_1016_j_lfs_2022_120489 crossref_primary_10_1111_fcp_12629 crossref_primary_10_3389_fimmu_2020_531910 crossref_primary_10_3390_ijms25052792 crossref_primary_10_1007_s10555_021_10017_z crossref_primary_10_1016_j_bcp_2023_115437 crossref_primary_10_1002_jcp_26138 crossref_primary_10_1039_D1FO03551G crossref_primary_10_1096_fj_202000467R crossref_primary_10_1021_acscatal_3c04954 crossref_primary_10_1021_acs_jpcb_3c01787 crossref_primary_10_1096_fj_201700817R crossref_primary_10_3389_fmicb_2017_02171 crossref_primary_10_1007_s40291_020_00460_z crossref_primary_10_1080_08958378_2024_2318389 crossref_primary_10_1053_j_jrn_2019_01_001 crossref_primary_10_3390_antiox11061213 crossref_primary_10_3897_rrpharmacology_4_27582 crossref_primary_10_1016_j_prostaglandins_2021_106539 crossref_primary_10_3389_fimmu_2020_02080 crossref_primary_10_1016_j_jacc_2018_08_1043 crossref_primary_10_25122_jml_2024_0081 crossref_primary_10_1016_j_pharmthera_2018_01_004 crossref_primary_10_1021_acs_jpcb_0c09147 crossref_primary_10_1016_j_joen_2022_01_003 crossref_primary_10_1051_fopen_2018008 crossref_primary_10_3389_fmed_2018_00316 crossref_primary_10_1016_j_bbi_2020_03_024 crossref_primary_10_1016_j_mehy_2020_109836 crossref_primary_10_3390_ijms21239283 crossref_primary_10_3390_metabo14060314 crossref_primary_10_1002_jpen_1746 crossref_primary_10_1016_j_bbalip_2023_159446 crossref_primary_10_1093_jas_skaa134 crossref_primary_10_1080_19490976_2019_1612662 crossref_primary_10_1038_s41467_023_43554_y crossref_primary_10_1038_s41385_018_0089_1 crossref_primary_10_1080_14728222_2019_1691525 crossref_primary_10_1111_bph_14647 crossref_primary_10_3390_ijms18030476 crossref_primary_10_3390_molecules29112421 crossref_primary_10_3390_md22010017 crossref_primary_10_1096_fj_201801017R crossref_primary_10_3390_medicina56090418 crossref_primary_10_3389_fimmu_2021_812171 crossref_primary_10_17749_2070_4909_2019_12_2_91_114 crossref_primary_10_1016_j_yexmp_2018_08_002 crossref_primary_10_1016_j_mehy_2020_109813 crossref_primary_10_1038_s41598_017_11188_y crossref_primary_10_1016_j_bbalip_2020_158702 crossref_primary_10_3389_fphar_2021_782660 crossref_primary_10_1016_j_plefa_2018_04_004 crossref_primary_10_1073_pnas_1807958115 crossref_primary_10_3390_ijms23063140 crossref_primary_10_12688_f1000research_153569_2 crossref_primary_10_3390_cells10040951 crossref_primary_10_12688_f1000research_153569_3 crossref_primary_10_1007_s13346_024_01588_9 crossref_primary_10_12688_f1000research_153569_1 crossref_primary_10_1016_j_intimp_2024_113901 crossref_primary_10_1089_ars_2017_7056 crossref_primary_10_3389_fnut_2022_998291 crossref_primary_10_1177_09727531241275347 crossref_primary_10_1016_j_bbamem_2017_03_014 crossref_primary_10_3390_ijms241310451 crossref_primary_10_1093_rheumatology_kez072 crossref_primary_10_1097_PRS_0000000000004835 crossref_primary_10_1016_j_addr_2024_115204 crossref_primary_10_1016_j_jep_2020_112563 crossref_primary_10_1016_j_pharmthera_2020_107670 |
| ContentType | Journal Article |
| Copyright | FASEB. |
| Copyright_xml | – notice: FASEB. |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1096/fj.201601222R |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1530-6860 |
| ExternalDocumentID | 28087575 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R01 GM038765 – fundername: NIGMS NIH HHS grantid: P01 GM095467 – fundername: NIDCR NIH HHS grantid: R01 DE025020 |
| GroupedDBID | --- -DZ -~X .55 0R~ 0VX 123 18M 1OB 1OC 29H 2WC 33P 34G 39C 3O- 4.4 53G 5GY 5RE 85S AAHQN AAMMB AAMNL AANLZ AAYCA ABCUV ABDNZ ABEFU ABJNI ABOCM ACCZN ACGFS ACIWK ACNCT ACPOU ACPRK ACXQS ACYGS ADKYN ADXHL ADZMN AEFGJ AEIGN AENEX AEUYR AEYWJ AFFNX AFFPM AFRAH AFWVQ AGCDD AGHNM AGXDD AGYGG AHBTC AI. AIDQK AIDYY AITYG AIURR AIZAD ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMYDB BFHJK BIYOS C1A CGR CS3 CUY CVF DCZOG DU5 D~5 E3Z EBS ECM EIF EJD F5P F9R H13 HGLYW HZ~ H~9 J5H L7B LATKE LEEKS MEWTI MVM NEJ NPM O9- OHT OVD Q-A RHI RJQFR ROL SAMSI SJN SUPJJ TEORI TFA TR2 TWZ U18 VH1 W8F WH7 WHG WOQ WXSBR X7M XJT XOL XSW Y6R YBU YHG YKV YNH YSK Z0Y ZCA ZE2 ZGI ZXP ~KM |
| ID | FETCH-LOGICAL-c566R-2d80106d18ca3deec28ac2f70ba35b92d052ec7e884c0cea32cc4549a685cc112 |
| IngestDate | Mon Jul 21 05:46:34 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | maresins leukocytes lipoxins omega-3 PUFA resolvins protectins |
| Language | English |
| License | FASEB. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c566R-2d80106d18ca3deec28ac2f70ba35b92d052ec7e884c0cea32cc4549a685cc112 |
| OpenAccessLink | https://www.fasebj.org/doi/pdf/10.1096/fj.201601222R |
| PMID | 28087575 |
| ParticipantIDs | pubmed_primary_28087575 |
| PublicationCentury | 2000 |
| PublicationDate | April 2017 |
| PublicationDateYYYYMMDD | 2017-04-01 |
| PublicationDate_xml | – month: 04 year: 2017 text: April 2017 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | The FASEB journal |
| PublicationTitleAlternate | FASEB J |
| PublicationYear | 2017 |
| SSID | ssj0001016 |
| Score | 2.6584506 |
| SecondaryResourceType | review_article |
| Snippet | Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 1273 |
| SubjectTerms | Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Clinical Trials as Topic Fatty Acids, Omega-3 - metabolism Humans Infections - drug therapy Infections - metabolism Inflammation Mediators - metabolism Inflammation Mediators - pharmacology Inflammation Mediators - therapeutic use |
| Title | Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28087575 |
| Volume | 31 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1JS8NAFIAHqwhexH2XOXgr0WSyTbxVaSmCHmoLvZXkZUJbaC00F_31vlmyWBWXSwiZZJjMl8y8N_MWQq6AsUgwEVoslC45NgD-cyyyRICTHQSeEyvbnMenoDvwHob-sEpvpbxL8uQa3r70K_kPVbyGXKWX7B_IlpXiBTxHvnhEwnj8HWMl8SmnlAzJai9EE09J21iVdozMWeZN0DOMXAVAabo5nkgbGOVgkqIWqtxbUPs2TdZOJSoZj6xxJqSP8GRpoptPq6-s03pu3zXrDdb2w-O4vqFv9nzMAgNOWpVdiigGRVQxuY77X4yaZuye1JcE1BDoMJ2b5NPYjMqS7NCptKcL5I4e69Xvw3dfzBQoxlWYff_n0pVQ2UVRgzRQaZBZUOXSjZmW5TKFCbKKLbn50A4ZEto8u6JeKDGjv0O2jX5AWxr2LlkT8z2yqTOGvu6TvEBO68gpAqIlcjyjiJxK5NQgv6UInCrgVAKnBXBaAaclcFVfBfyADDrt_n3XMokzLEDpvGexlEtVP3U4xG4qBDAeA8tCO4ldP4lYavtMQCg498AGEbsMwPO9KA64D4AS-CFZn7_MxTGhroMKr4iwNEg84WZJ4GSJE4rM8yHhUXxCjnR3jRY6Osqo6MjTb0vOyFb1nZ2TjQx_R3GBsl2eXCpm77zWUO4 |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Treating+inflammation+and+infection+in+the+21st+century%3A+new+hints+from+decoding+resolution+mediators+and+mechanisms&rft.jtitle=The+FASEB+journal&rft.au=Serhan%2C+Charles+N&rft.date=2017-04-01&rft.eissn=1530-6860&rft.volume=31&rft.issue=4&rft.spage=1273&rft_id=info:doi/10.1096%2Ffj.201601222R&rft_id=info%3Apmid%2F28087575&rft_id=info%3Apmid%2F28087575&rft.externalDocID=28087575 |