Targeting DNA damage response in cancer therapy

• Published in: Cancer science Vol. 105; no. 4; pp. 370 - 388
• Main Authors: Hosoya, Noriko, Miyagawa, Kiyoshi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2014; Blackwell Publishing Ltd
• Subjects: Apoptosis; Ataxia; Biomarkers; Cancer; Cancer therapies; Cancer therapy; Cell cycle; Chemotherapy; Clinical trials; Complementary DNA; Defects; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - genetics; DNA damage response; DNA repair; DNA Repair - genetics; Enzyme Inhibitors - therapeutic use; Glycoproteins; Homologous Recombination; Humans; Hypoxia; Kinases; Lethality; Mutation; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; PARP inhibitors; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Proteins; Radiation therapy; Review; Ribose; Signal Transduction; synthetic lethality; DNA damage response; DNA repair; Cancer therapy; PARP inhibitors; synthetic lethality

Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing DNA damage. DNA damage is normally recognized and repaired by the intrinsic DNA damage response machinery. If the damaged lesions are successfully repaired, the cells will survive. In order to specifically and...