Ciliated cell damage in the bronchial epithelium of asthmatics and non-asthmatics

• Published in: Clinical and experimental allergy Vol. 23; no. 3; pp. 185 - 189
• Main Authors: MONTEFORT, S., DJUKANOVIĆ, R., HOLGATE, S. T., ROCHE, W. R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.1993; Blackwell
• Subjects: Adult; Allergic diseases; Asthma; Asthma - pathology; Biological and medical sciences; Biopsy; Bronchi - pathology; Bronchi - ultrastructure; Cell adhesion molecules; Cilia - pathology; Cilia - ultrastructure; Cytotoxicity; Epithelial cells; Epithelium; Epithelium - pathology; Epithelium - ultrastructure; Female; Humans; Hydrolyzable Tannins; Immunopathology; Injuries; Male; Medical sciences; Middle Aged; Mucosa; Respiratory and ent allergic diseases; Sectioning; Tannic acid; Human; Bronchus; Pathology; Exploration; Epithelium; Respiratory disease

Summary The importance of bronchial epithelial shedding in the pathogenesis of asthma has been highlighted by many investigators as a potential mechanism for bronchial hyperresponsiveness. It has been suggested that this disruption is the result of cytotoxic injury leading to shedding of damaged cel...