Traumatic brain injury increases levels of miR‐21 in extracellular vesicles: implications for neuroinflammation

• Published in: FEBS open bio Vol. 6; no. 8; pp. 835 - 846
• Main Authors: Harrison, Emily B., Hochfelder, Colleen G., Lamberty, Benjamin G., Meays, Brittney M., Morsey, Brenda M., Kelso, Matthew L., Fox, Howard S., Yelamanchili, Sowmya V.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2016; John Wiley and Sons Inc
• Subjects: Alzheimer's disease; Brain research; Cell interactions; controlled cortical impact; Encephalitis; Ethanol; exosomes; Experiments; Extracellular vesicles; Hydration; Inflammation; Laboratory animals; Membrane vesicles; Microglia; microRNA; MicroRNAs; miRNA; neuroinflammation; Neurons; secondary injury; Studies; Surgery; Traumatic brain injury; United States > US; microRNA; controlled cortical impact; secondary injury; neuroinflammation; microglia; exosomes

Traumatic brain injury (TBI) is an important health concern and effective treatment strategies remain elusive. Understanding the complex multicellular response to TBI may provide new avenues for intervention. In the context of TBI, cell–cell communication is critical. One relatively unexplored form...